| Objective: Observe the clinical efficacy of dioscorea Pills in the treatment of cancer-related fatigue in patients with colorectal cancer chemotherapy,as well as the improvement of the quality of life of patients,and observe its safety.Objectively evaluate the impact of dioscorea Pills on fatigue,and provide a certain basis for the clinical treatment of cancer-related fatigue.Methods: 1.The 72 patients with colorectal cancer who met the inclusion criteria were randomly numbered and divided into two groups.The control group was given conventional treatment and health education for cancer-related fatigue.The treatment group was given yam decoction on the basis of the treatment of the control group.,15 days a course of treatment,observe two courses of treatment.Both groups were evaluated with Piper Fatigue Inventory,KPS score,quality of life EORTC QLQ(30)score,sleep quality and safety indicators before treatment,after one course of treatment,and after two courses of treatment.2.All data recorded in this study were analyzed using SPSS21.0software.Results: The treatment group dropped out of 2 cases in the first course of treatment(1case could not take Chinese medicine on time,1 case quit actively),and finally a total of70 patients completed clinical observation,34 cases in the treatment group and 36 cases in the control group.1.Before treatment,the basic data of the patient(age,gender,tumor location,clinical stage,etc.),Piper fatigue survey scale,KPS score,Pittsburgh sleep quality index scale and quality of life EORTC QLQ(30)score,For comparison,the differences between the two groups were not statistically significant and comparable.2.Piper Fatigue Scale Score: After treatment,the fatigue of the two groups was reduced,and the analysis within the two treatment courses was statistically significant(P<0.05);after one treatment,the control group had an effective rate of 8.3% and a stable rate 75%,the inefficiency was 16.7%;the effective rate in the treatment group was 26.5%,the stable rate was 61.8%,and the inefficiency was 11.8%.There was no significant difference in the effective rate between the two groups(P>0.05);after two courses of treatment,the control The effective rate in the group was 22.2%,the stable rate was66.7%,and the inefficiency was 11.1%;the effective rate in the treatment group was67.6%,the stable rate was 29.4%,and the inefficiency was 2.9%.The treatment group was significantly better than the control group.The difference was statistically significant(P<0.01);3.KPS score,the scores of the two groups increased after treatment,and the differences in the analysis of the two courses of treatment time points were statistically significant;after one course of treatment,there was no statistical difference in the analysis between the two groups Scientific significance(P>0.05),the difference between the two groups after two courses of treatment was statistically significant(P<0.05);4.Sleep quality score: Sleep quality score: After treatment,the Pittsburgh sleep quality index scores of the two groups decreased,and the differences between the analysis and the analysis between the groups at the two treatment time points were statistically significant(P<0.05)5.Quality of life score EORTC QLQ(30): The scores of the two groups decreased after treatment,and the two treatment time point groups The differences in internal analysis were statistically significant;after one course of treatment,there was no statistically significant difference between the two groups(P>0.05),and the difference between the two groups after two courses of treatment was statistically significant;6.Safety indicators: According to the results of blood routine and liver and kidney function,the treatment group and the control group had fewer severe bone marrow suppression and abnormal liver and kidney function after treatment,and there was no statistically significant difference between the two groups at P>0.05.Conclusions: 1.Dioscorea batatas can significantly reduce the fatigue state of four dimensions of behavior,emotion,perception and cognition of patients with colorectal cancer CRF,reduce fatigue,and improve the physical status,sleep quality,and quality of life of patients with colorectal cancer CRF.2.Dioscorea batatas can reduce the incidence of bone marrow suppression after chemotherapy,and it has good safety in clinical application. |
PDF Full Text Request