Clinical Observation On The Treatment Of Generalized Anxiety Disorder With Deficiency Of Heart And Spleen By "Sancai Matching Points" Method Combined With Western Medicine

Objective:This paper investigates the clinical efficacy of the "Sancai Matching Point" method combined with paroxetine hydrochloride in the treatment of generalized anxiety disorder(heart and spleen deficiency type),with the aim of finding an alternative comprehensive treatment plan for the clinical treatment of generalized anxiety disorder.Methods:Seventy subjects who met the diagnosis of generalized anxiety disorder(heart and spleen deficiency)and were treated at the West China Hospital Mental Health Centre of Sichuan University were included in this study.The subjects were randomly divided 1:1 into treatment and control groups using SPSS19.0.The control group received 20 mg of paroxetine hydrochloride orally once a day,which could be increased by 10 mg per week according to the clinical response of the patients,but not more than 40 mg.The treatment group was treated by acupuncture 3 times a week.The two groups were treated for 6 weeks and followed up after 1 month.HAMA,somatic symptom factor,psychiatric symptom factor and SAS scores were observed at the 2nd,4th and 6th weeks of treatment to compare the anxiety levels of the two groups;the improvement in Chinese medicine symptoms and quality of life were observed before and after treatment;adverse reactions were recorded at any time and the data obtained were analysed for clinical efficacy and safety.Results:1.Baseline results: Subjects in both groups were consistent at baseline in terms of age,gender,duration of illness,Hamilton Anxiety Inventory(HAMA),Self-Assessment Scale of Anxiety(SAS),World Health Organization Brief Quality of Life Scale(WHOQOL-BREF),and TCM symptom scores2.Curative effect:(1)Hamilton Anxiety Scale(HAMA): For comparison within groups,the total HAMA score decreased at the end of treatment in both groups compared to the pre-treatment period,with a statistical difference(P < 0.05),and the total HAMA score and its two factors(psychiatric symptoms and psychotic symptoms factor)decreased faster in the treatment group at week 2,P < 0.05,while P > 0.05 in the control group,indicating that both protocols improved the patients’ anxiety symptoms,with the treatment group having a faster onset of effect.In comparison between groups,the total HAMA score was lower in the treatment group than in the control group,with statistical differences during treatment and at follow-up(P < 0.05),while there was a tendency for the control group to have a slight rebound in the follow-up score,indicating that the treatment group was more effective than the control group and had better long-term efficacy(2)Self-rating Anxiety Scale(SAS):When comparing within groups,the SAS scores of patients in both groups decreased to varying degrees during the treatment period,with P <0.05 indicating that both protocols improved the patients’ anxiety status.When comparing between groups,there were statistical differences at all time points,with P < 0.05 after 2weeks of treatment and P < 0.01 at the end of treatment,with the treatment group consistently outperforming the control group(3)WHOQOL-BREF scale scores: when comparing within groups,both groups had higher scores than before treatment,P < 0.05,indicating that both protocols improved the quality of life of the patients.When comparing between groups,there was a statistical difference in the WHOQOL-BREF total score at the end of treatment(P < 0.05),in psychological and physical health,but not in social relationships and surroundings(P > 0.05).The treatment group had higher scores than the control group at follow-up and at P < 0.05,indicating better long-term outcomes in the treatment group.(4)TCM syndrome score: In the intra-group comparison,the scores of both groups decreased compared to the pre-treatment period,and there was a statistical difference;in the inter-group comparison,the scores of the treatment group were lower than those of the control group at the end of the treatment,p < 0.05.This indicates that both protocols could improve the patients’ TCM symptoms,but the treatment group was superior(5)Adverse reactions: the number and degree of adverse reactions in the treatment group were less than those in the control group,with statistical difference.Conclusion:(1)"However,the "Sancai acupoint matching " method was more effective than paroxetine hydrochloride alone in improving the degree of anxiety,mental and physical symptoms,and quality of life,and had a better sustained effect than paroxetine hydrochloride alone(2)The combination of "Sancai acupoint matching " and Paroxetine Hydrochloride can accelerate the onset of symptoms and increase patients’ confidence in treatment,making it a comprehensive treatment option.