Professor Li Leyu’s Experience In Treating Menopausal Insomnia With Pure Traditional Chinese Medicine

ObjectiveUsing the software of "traditional Chinese Medicine inheritance Computing platform" V3.0,this paper makes a retrospective analysis of Professor Li Leyu’s medical records in the treatment of menopausal insomnia,and excavates Professor Li’s clinical medication experience and treatment rules based on syndrome differentiation,so that Professor Li’s TCM experience can be effectively inherited and developed,and can really guide clinical practice.MethodsBy using the method of retrospective analysis,the medical record information of Professor Li’s outpatient diagnosis and treatment of climacteric insomnia from 2015 to2020 was collected by searching the medical record system,and the patients were selected according to the proposed case screening criteria,inclusion criteria and exclusion criteria.The 318 medical records meeting the criteria were standardized in terms,and entered into TCMISS V3.0 software,using the functions of frequency analysis,cluster analysis and association rule analysis.To study Professor Li’s prescription rule and clinical experience of pure traditional Chinese medicine in the treatment of climacteric insomnia from the aspects of drug meridian and taste distribution,drug efficacy and frequency,high frequency drug and common dosage,drug core combination and so on.ResultsThrough the systematic analysis of 318 cases,the main manifestations of climacteric insomnia are insomnia and menstrual disorders,with hot flashes,night sweats,cold phobia and other symptoms,mainly deficiency.In the aspect of tongue pulse,the tongue image is light red,dim and light,while the moss image is white and thin white,and the pulse is dominated by veinlets.In the aspects of four qi,five flavors and meridian,the drugs of plain and sweet are mainly,and the drugs belonging to the meridians of heart,liver and spleen account for more than half.From the perspective of drug efficacy,deficiency-tonifying drugs accounted for the most,followed by tranquilizing drugs.In terms of the distribution of TCM syndrome types,the main syndrome is liver depression syndrome,followed by heart and spleen deficiency,kidney yang deficiency,heart blood deficiency syndrome,kidney yang deficiency syndrome and Ying Wei disharmony syndrome.The top five high-frequency drugs(frequency>100 times)are Wild jujube seed,grilled licorice,Polygonum multiflorum,albizzia bark and oyster shell.The high frequency prescriptions(frequency≥10 times)included Guipi decoction,Bupleurum plus Dragon Bone Oyster soup,Jinkui Shenqi Pill,Chaihu Guizhi dry Ginger decoction,Huanglian Ejiao decoction,Yougui Pill and Sanhuang Anmian decoction.The frequency of Guipi decoction and Bupleurum plus keel Oyster soup was more than 80.For different TCM syndrome types,there are commonly used prescriptions,such as liver depression syndrome commonly used Chaihu plus dragon bone Oyster soup,heart and spleen deficiency syndrome,heart blood deficiency syndrome commonly used Guipi decoction and so on.In the analysis of association rules,when the confidence is 0.9 and the number of supports is159,there are 9 common drug patterns and 6 drug association rules composed of 6 kinds of drugs,among which "Wild jujube seed-Polygonum multiflorum" has the highest frequency.Seven new prescriptions were obtained by using cluster analysis,and the most frequent prescriptions were "grilled licorice,Wild jujube seed,poria with hostwood,astragalus,black jujube,Angelica sinensis,Polygonum multiflorum and Radix Aucklandiae".ConclusionClimacteric insomnia is mainly deficiency,which is located in the liver and heart and is related to the spleen and kidney.The most common pathogenesis is liver depression and deficiency of both heart and spleen.Professor Li Leyu often uses drugs with flat nature and sweet taste in the treatment of the disease,and pay attention to protecting stomach qi.The method of tonifying deficiency and purging excess is often used to reconcile Ying Wei,qi and blood,yin and yang,and the most frequently used drugs are tonifying deficiency medicine and tranquilizing medicine.Professor Li attaches importance to the four diagnoses and flexibly adds and subtracts drugs in combination with clinical practice,and the prescriptions have their own characteristics;they praise classical prescriptions and collect many prescriptions,often with classical prescriptions as the base,and the most commonly used prescriptions include Guipi decoction,Bupleurum plus keel Oyster soup,and so on.Professor Li Leyu pays attention to the individual factors such as physique,spirit and psychology of patients in the process of diagnosis and treatment,and improves the curative effect of traditional Chinese medicine through the thinking path of "person-syndrome-prescription".