Therapeutic Effect Of Zhongfeng Xingnao Liquid Combined With Butylphthalide In The Treatment Of Acute Cerebral Infarction Of Anterior Circulation With Large Vessel Stenosis

ObjectiveBy observing the clinical efficacy of ZFXNL combined with butylphthalide sequential treatment on patients with acute anterior circulation large vessel stenosis cerebral infarction.By observing、comparing and anaynasising the data of clinical efficacy,explore an integrated traditional Chinese and Western medicine treatment plan,that can effectively improve the symptoms and prognosis of patients with largevessel stenosis cerebral infarction,and cannot be treated with thrombolysis and endovascular treatment.At the same time,the safety of this integrated traditional Chinese and western medicine treatment plan will be evaluated.MethodsThis study will be hospitalized in the emergency department of Sichuan Provincial Hospital of TCM from January 2019 to November 2020,and the 60 patients were diagnosed with acute anterior circulation large vessel stenosis cerebral infarction.According to the principle of randomization and control,divided all patients into a treatment group and a control group,30 cases in each group.The treatment plan of the control group is the butylphthalide sequential treatment group plus the conventional western medicine treatment,and the treatment group was the control group’s plan combined with ZFXNL,and the total course of is 90 days.Observe and compare the changes of NIHSS、m RS、Barthel index、MMSE and TCM syndrome score of the two groups at different time,as well,recorded the complications and adverse reactions.Result1.Total curative effect: The two group’s total effective rate is 92.9% and 80.8%,and the apparent control rate is 64.3% and 50%;The total effective rate of the treatment group is higher.2.NIHSS: Before treatment,the difference in NIHSS score(P>0.05)between the two groups hasn’t any significant in statistics;after 90 days,the decrease in NIHSS of the treatment group was greater.Via statistical analysis,P<0.05,with statistics Significance;it shows that the treatment group is better than the control group in improving the neurological damage of patients.3.Barthel index and m RS: Before treatment,there was no statistically significant difference in Barthel index and m RS score(P>0.05)between the two groups;after 90 days,P<0.05,the difference was statistically significant;after 90 days,the barthel index and m RS of the two groups had improved,but the improvement of the treatment group was higher,and the prognosis was better,too.4.MMSE: After treatment,the MMSE scores of the two groups of patients were improved compared to the before,but the P values of the two groups before and after treatment were both greater than 0.05,indicating that there was no significant statistically significant difference in the effects of the two groups of medication regimens on cognitive function.5.TCM syndrome score: The scores of TCM syndromes(P>0.05)of the two groups before treatment are comparable.After 90 days of treatment,they are better than before admission,but the improvement of the treatment group is higher than that of the control group,indicating that the treatment with the control group Compared with the program,the treatment group program can better improve the TCM syndrome score.ConclusionZFXNL combined with butylphthalide sequential therapy has certain advantages in improving the neurological damage in patients with acute anterior circulation and large vessel stenosis cerebral infarction,and to a certain extent,it can improve the short-term prognosis of this kind of patients.The security of this program is reliable.