Analysis Of Risk Factors Associated With Impulse Control Disorder With Parkinson’s Disease In Northern China

Background:Impulse control disorder is a non motor symptom of Parkinson’s disease,which is not rare,and there is still a lack of effective treatment.Therefore,it is particularly important to identify its risk factors and early prevention.However,the research results on its risk factors are controversial,and the incidence of impulse control disorder has obvious regional characteristics.There is still a lack of such research in northern China.This study aims to provide evidence for further diagnosis and treatment of Parkinson disease by analyzing the incidence rate and risk factors of impulse control disorder in northern China.Methods:In this study,238 patients with Parkinson’s disease were choosed from the Department of Neurology of China-Japan Friendship Hospital Affiliated Jilin University.Each patient was screened by the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s disease（QUIP）.If one of the questionnaire was positive,they were classified as impulse control disorder group,the patients who were all negative were classified into the non-impulse control disorder group.Compare the demographic and epidemiological characteristics of the two groups and analyze their risk factors.Results:Among the 238 patients with Parkinson’s disease,31 cases were positive for QUIP screening,the incidence rate was 13%,The prevalence of QUIP positivity in our patients was as follows:pathological gambling（2.4%）,compulsive sexual behavior（2.4%）,compulsive buying（5.7%）,compulsive eating（4.9%）.Patients with two or more impulse control disorders behaviors accounted for 4.1%;Longer PD duration、the use of dopamine agonists、dosage of pramipexole、daily equivalent dosage of levodopa、motor symptoms、non-motor symptom、depression、anxiety、rapid eye movement sleep behavior disorder are related to ICD.Conclusion:RBD is an independent risk factor for impulse control disorder that is not rare in patients with Parkinson’s disease.