Correlation Between Cognitive Impairment And Event-related Potential P300 Latency In Patients With Acute Temporal And Occipital Lobe Infarction

Objective:To explore the relationship between the size of acute temporal lobe or occipital lobe infarction and cognitive dysfunction,and to analyze the value of event-related potential P300 latency in evaluating cognitive dysfunction.Methods:Prospective study.A total of 100 patients with acute temporal lobe or occipital lobe infarction from the Department of Neurology,Bengbu Third People’s Hospital from January 2020 to July 2021 were included as the research objects,including 52 males and 48 females,aged 50-82（70.20±7.85）.aged 5-9（5.28±0.87）years of education,21patients had a history of smoking,17 patients had a history of drinking,36 patients had a history of hypertension,24 patients had a history of diabetes,and 10 patients had a history of coronary heart disease.All patients underwent brain MRI scans and were grouped according to the size of the infarct:observation group A（41 cases）with infarction≥30 cm~3,observation group B（59 cases）with infarction<30 cm~3.50age-matched healthy subjects in the same hospital were selected as the control group,including 25 males and 25 females,aged 50-82（71.32±7.22）years old.The clinical baseline data such as gender,age,years of education,smoking history,drinking history,hypertension,diabetes mellitus,coronary heart disease history,etc.were compared among the three groups;the Montreal Cognitive Assessment（MoCA）scale was used to evaluate the cognition of all subjects function,and measured the P300 incubation period of all subjects.The observation group was tested when the condition was stable after 1week of hospitalization,and the control group was tested on the day of physical examination.Pearson correlation analysis was used to evaluate the MoCA score and P300 incubation period of the three groups of subjects.correlation.Results:There was no significant difference in baseline data among the three groups of subjects（all P>0.05）.The MoCA scores of observation group A,observation group B and control group were（26.00±2.97）,（27.86±1.57）and（28.96±1.42）respectively,and the P300 latency was（374.17±55.92）ms,（315.17±40.35）)ms and（286.18±18.30）ms,there were significant differences among the three groups（F=24.64,55.44,P<0.001）.There was a statistically significant difference between the two groups in the observation group（t=-3.67,5.72,both P<0.001）.Those who met the criteria for cognitive impairment accounted for 47.4%（18/41）in observation group A,32.29%（19/59）in observation group B,and 2%（1/50）in control group.There were differences between the groups.Statistical significance（χ2=23.34,P<0.001）.Compared with the control group,the MoCA score in the observation group was decreased,and the P300latency was prolonged.Pearson correlation analysis showed that P300 latency was negatively correlated with MoCA score（r=-0.25 in observation group A,r=-0.14 in observation group B,and r=-0.05 in control group,all P<0.01）.Conclusion:1.The size of acute temporal lobe or occipital lobe infarction is a relevant factor affecting the cognitive impairment of patients。2.The P300 latency and MoCA scale have good consistency in the evaluation results,and the P300 combined with MoCA scale is used to detect early cognitive dysfunction in patients.sensitive.