Cross-cultural Adaptation And Evaluation Of The Screening Effect Of The G-8 Questionnaire On Frailty In Elderly Patients With Malignant Tumor

ObjectivesCross-culture adjustment of the Geriatric 8 questionnaire and comparison with the Chinese version of the Vulnerable Elders Survey 13-questionnaire and Chinese version of Groningen Frailty Indicator for Frailty screening in elderly patients with malignant tumor.Methods（1）After obtaining the authorization of the original G-8 questionnaire,the translation was carried out in accordance with the Brislin translation model and the Chinese version of the G-8 questionnaire was finalized according to the Cross-cultural debugging guide of Beaton.（2）Using the convenient sampling method,217 elderly patients with malignant tumors were selected as research objects in a tertiary hospital in Lanzhou City,Gansu Province,and the items,screening threshold,validity,reliability and screening test evaluation indexes of the Chinese version of G-8 questionnaire were analyzed.（3）Using convenient sampling method,417 elderly patients with malignant tumors were selected as research objects in a tertiary hospital in Lanzhou City,Gansu Province.The Chinese version of G-8,VES-13 and GFI were compared with Comprehensive Geriatric Assessment（CGA）.Receiver Operating Characteristic Curve（ROC）was plotted and the sensitivity（SN）and specificity（ROC）of the three tools were calculated and compared.SP,Positive Predictive Value（PPV）,Negative Predictive Value（NPV）,Youden’s index（YI）,Area Under Roc Curve（AUC）and practicability.Results（1）The Chinese version of G-8 includes the reduction of food intake in the past 3months,weight loss,mobility,body mass index,multiple medications,selfassessment health status,psychological problems,8 items of age,a total score of 0 to17 points,a score of ≤ 14 points of frailty,and further comprehensive assessment of the elderly is required.（2）The results of statistical analysis show that the CR values of each item reach a significant difference level,and the correlation coefficients of each item and the total score range from 0.316 to 0.808（P<0.001）,and the α values of all features after deletion will not increase the Cronbach’s α coefficient（0.716）of the Chinese version of G8.The content validity（S-CVI）at the scale level was 0.91,the Pearson correlation coefficient for the total score of each entry scale was 0.316 to 0.808,the sensitivity was 84.33%,the specificity was 76.87%,and the area under the curve（AUC）value was 0.894（P<0.001）.Cronbach’s α coefficient is 0.716 and the retest reliability coefficient is 0.994.The Chinese version of G-8 is determined to be 14,and≤14 is considered as frailty.（3）The diagnostic rates of debilitation in G-8,VES-13 and GFI were 48.9%,36.3% and 35.1%,respectively;the sensitivity was 83.4%,68.6%,and 66.9%,the specificity was 74.4%,85.6%,and 86.4%,respectively,and the AUC values were0.880,0.856,and 0.879,respectively,the Youden’s index was 0.58,0.54 and 0.53,respectively.Conclusion（1）The Chinese version of G-8 questionnaire has good reliability,validity and sensitivity for screening frailty in elderly patients with malignant tumor.（2）Comparing the frailty screening effect of the Chinese version of G-8,VES-13 and GFI in elderly patients with malignant tumor,the Chinese version of G-8questionnaire has the highest sensitivity and is most suitable for frailty screening in elderly patients with malignant tumor.