Preliminary Study On The Appropriate Syndromes And Medication Rules Of Dingchuan Decoction In The Treatment Of Asthmatic Diseases In Children

Objective: To clarify the appropriate syndromes and medication rules of Dingchuan Decoction in the treatment of asthmatic diseases in children,and to provide reference for the clinical application of Dingchuan Decoction.Methods: The literatures on Dingchuan Decoction published from January2000 to January 2021 were collected.Relevant research elements were extracted,and Excel and SPSS 26.0 software were used for data analysis of the research elements.Results:1.A total of 40 literatures were included,45 evidences were collected,and 45 prescriptions of Dingchuan Decoction were added or subtracted.2.Syndrome pattern: There were 13 specific syndromes,including 4main syndromes and 9 concurrent syndromes.Among the main syndromes,phlegm-heat obstruction of the lung(71.11%)was the first,followed by phlegm-dampness obstruction of the lung(22.22%),wind-cold obstruction of the lung and cold phlegm-cold obstruction of the lung(2.22%)respectively.9 and the sense of syndrome and table card,outside cold table each 8.89%,pulmonary qi deficiency syndrome,lung Yin deficiency syndrome,spleen deficiency syndrome,blood stasis syndrome,outside wind card table each 4.44%,kidney syndrome,external heat table each 2.22%,and syndrome syndrome can be roughly classified as table(24.44%),deficiency syndrome(15.56%),blood stasis(4.44%).3.Drug use rule: A total of 54 drugs were extracted,with a total drug frequency of 475 times.Among them,the original prescription of Dingchuan Decoction was: ephedra 45 times,licorice 43 times,colt flower41 times,pinellia 41 times,Perilla seed 41 times,scutellaria 40 times,mulberry white bark 38 times,almond 39 times,ginkgo 31 times,with a total frequency of 359 times,and the use frequency of each drug was more than 60%.The usual dose and dose range of each drug in the original formula are: ephedra 3g,3-9g,licorice 3g,2.2-6g,colt flower 6g,5-10 g,pinellia 9g,3-9g,Perilla seed 6g,3.7-10 g,scutellaria 3g,3-9g,mulberry white bark 6g,3-11.3g,almond 6g,3-9g,ginkgo 6g,4-12 g.Flavored medications on a total of 45,a total of 116 frequency,of which more than 10% of the frequency lumbricus(24.44%),semen lepidii(17.78%),radix paeoniae alba(13.33%),uncaria(13.33%),fructus(11.11%),dry(11.11%),fruit of Chinese magnoliavine(11.11%),these drugs commonly used dose and dose were lumbricus 10 g,7--10 g,6 g,semen lepidii 5.7 15.9 g,radix paeoniae alba,9-13.5 g,12 g uncaria 10 g,2-10 g,shoot dry 5 g,3.8--7.2 g,Trichosanthis 8g,4.8-10.4g,Schisandra6 g,3-6g.There were 11 categories of flavoring drugs,the first 6 were phlegm-reducing,cough-relieving and antiasthmatic drugs(21.55%),antiphlegm-relieving drugs(19.83%),liver-soothing and wind-relieving drugs(17.24%),defect-tonifying drugs(15.52%),heat-clearing drugs(6.90%),and food disinfestation drugs(6.90%).According to the analysis of drug properties,taste and frequency of returning meridian,the medicinal properties mainly included cold(including mild cold and severe cold)(50.86%),warm(including mild cold)(35.34%),flat(8.62%)and cool(5.17%).The main medicinal tastes were sweet(31.91%),bitter(including slightly bitter)(27.13%),spicy(22.87%),salty(9.04%)and sour(7.98%).The drug channels mainly included lung channels(26.28%),liver channels(16.42%),spleen channels(15.33%),stomach channels(12.04%)and heart channels(10.58%).By cluster analysis and factor analysis of the 16 drugs with the highest frequency,the drugs could be roughly grouped into four categories: the first category: cassia twood,asarum,trichosanthis,schisandra fruit;The second category: Fritillaria fritillae and Ophiopogon ophiopogonis;The third category: Paeonia lactiflora,Uncaria,Cicada slough,Terranosaurus;Fourth category: Hawthorn,Divine Comedy,Gypsum,Draba nemidia,Radix pseudostellariae.Six main components were obtained: Hawthorn,Radix Radix,Divine Comedy,Gypsum,Draba nemorosa and Radix Radix Radix.Trichosanthis,cassia twig,Schisandra fruit,Asarum;White peony,ground dragon,trichosanthis,cassia twigs,asarum;Fritillaries,Ophiopogon;Trichosanthis,hawthorn,Divine Comedy,Radix Pseudostellariae,Schisandra;Cassia twig,Radix pseudoginseng,Asarum.Conclusion:1.Dingchuan Decoction is often used to treat phlegm-heat obstructing the lung syndrome,phlegm-dampness obstructing the lung syndrome,wind-cold closing the lung syndrome,cold phlegm-closed the lung syndrome,either with the syndromes of surface syndrome,or with the syndromes of deficiency of clamping,or with blood stasis syndrome.2.The original prescription drugs of Dingchuan Decoction are the main components in clinical application,and the common dose and dose range of each drug are basically the same as described in the textbook of Chinese Medicine.3.In the clinical application of Dingchuan Decoction,it is often compatible with phlegm relieving cough and antiasthmatic drugs,antiphlegm relieving drugs,liver soothing and wind soothing drugs,deficiency tonifying drugs and heat-clearing drugs;The compatibility of drugs is more cold and warm;The medicine tastes sweet,bitter and spicy;The main drug channels were lung,liver,spleen and stomach.The dose and dose range of compatible drugs are basically the same as those described in the textbook of Chinese Medicine.A total of 4 cluster components and 6principal components were obtained,and each cluster and component can treat various concurrent syndromes.Dingchuan Decoction can be used in the clinical treatment of asthmatic diseases in children.