| In the context of deepening globalization and the impact of COVID-19,market competition is becoming increasingly fierce,and manufacturers are facing increasingly severe challenges.In order to better adapt to the needs of the market,relevant enterprises urgently need to improve their competitiveness.L Company is a pharmaceutical manufacturer in the east of China.,mainly engaged in the production of various types of small volume injection,However,there are many wastes in the production process,which leads to high production costs.Therefore,this thesis carries out lean research on the injection production line of L CompanyFirstly,this thesis analyzed the value stream of VC aqueous injection,the main production product of L company,by means of on-site investigation and drawing value stream diagram,and found that the main problems of complex logistics path,long distance and high cost existed in its production process.After identifying the main problems,the process flow chart and fishbone chart were used to analyze the whole production process of injectable water.It was found that the unreasonable layout of the workshop was the main cause of the problem.Secondly,through the System Layout Planning method,the inter-relations among the units in the production workshop of injectable water were analyzed,and the restrictions of the planning layout were made clear,on this basis,three different layout optimization schemes are designed and the feasibility of the schemes is verified.Then,the effectiveness of these optimized solutions in reducing the logistics intensity was verified by Flexsim software.The results show that the three schemes can reduce the logistics intensity by 7.9%,18.8%and 23.9% respectively.Finally,the comprehensive effect of each solution in four aspects of logistics relationship,non-logistics relationship,transformation cost,and upgrade space was considered,and a hierarchical analysis model containing 4 criterion layers and 12 sub-criteria layers was established to comprehensively evaluate the layout optimization solutions by decomposing each aspect into three different evaluation indexes,and the results showed that the weights of the three layout optimization schemes are 17.23%,23.05% and 59.72%.According to the result,Scheme 3 is selected as the best implementation scheme.In addition,three measures are put forward to improve the effect of the scheme,which are standardization of Operation Standard,promotion of staff participation and establishment and improvement of incentive mechanism.The research on the optimization of the layout of the aqueous injection production plant of Company L achieved good results,effectively reducing the logistics costs in the production of aqueous injection in Company L,and establishing corresponding safeguards.In solving the production problems of Company L,it also provides a case study for the optimization of workshop layout for pharmaceutical manufacturing enterprises,which can hopefully play a certain reference in the optimization of layout for similar enterprises.The thesis has 26 figures,27 tables and 91 references. |