| Objective: To study the relationship between Monocyte-to-High Density Lipoprotein cholesterol ratio(MHR)and carotid atherosclerosis(CAS)in Korean and han nationality in Yan Bian,providing new ideas for early identification of CAS in Korean and Han T2 DM patients and early intervention in the development of CAS.Methods: The study mainly focused on T2 DM patients who were hospitalized in the Endocrinology Department of Yan Bian University Affiliated Hospital from January2019 to October 2021.A total of 401 people,including 197 Korean nationality and 204 Han nationality.The enrolled patients were divided into groups according to the carotid intima-media thickness measured by carotid color Doppler ultrasound: 142 patients in the normal carotid artery group and 259 patients in the carotid atherosclerosis group(CAS group).The age,race,gender,weight,height,history of smoking and drinking,duration of diabetes,carotid artery intima-media thickness(CIMT),fasting blood glucose(FBG),monocytes,High density lipoprotein(HDL-C),low density lipoprotein(LDL-C),total cholesterol(TC),triglyceride(TG),glycosylated hemoglobin(Hb Alc),cystatin C(Cys C),creatinine(CREA).Result:1.In all study subjects,the age,SBP,BMI,course of disease,Cys C,and MHR in the CAS group were higher than those in the normal carotid group,the difference was statistically significant(all P<0.05),the HDL-C in the normal carotid froup was higher than those in the CAS group,the difference was statistically significant(P<0.05).2.In Korean patients,the age,smoking,SBP,course of disease,Cys C,and MHR in the CAS group were higher than those in the normal carotid group,the difference was statistically significant(all P<0.05),the HDL-C in the normal carotid froup was higher than those in the CAS group,the difference was statistically significant(P<0.05).3.In Han patients,the age,SBP,BMI,course of disease,Cys C,and MHR in the CAS group were higher than those in the normal carotid group,the difference was statistically significant(all P<0.05),the HDL-C in the normal carotid froup was higher than those in the CAS group,the difference was statistically significant(P<0.05).4.In all CAS patients,the age,monocytes and MHR of Korean patients were higher than those of Han patients,and the difference was statistically significant(all P<0.05).5.The risk factors of T2 DM complicated with CAS in all study subjects were age(OR=1.111),MHR>0.49(OR=4.604),course of disease(OR=1.051)(all P<0.05).6.The risk factors of Korean T2 DM complicated with CAS were age(OR=1.112),MHR>0.47(OR=3.654)(all P<0.05).7.The risk factors of Han T2 DM complicated with CAS were age(OR=1.120),MHR>0.49(OR=5.236),course of disease(OR=1.109),BMI(OR=0.887),and the protective factor was HDL(OR=0.324)(all P<0.05).8.MHR has positive correlation with monocyte count,TG,Cys C and CREA,and has negative correlation with HDL(all P<0.05).9.The ROC curve of MHR for all subjects with T2 DM complicated with CAS showed: AUC was 0.642,the P<0.001,the 95% CI was 0.592-0.689,the best critical value was 0.49,the sensitivity was 40.2%,and the specificity was 86.6%,suggesting that MHR has a great predictive value for T2 DM complicated with CAS in all study subjects.10.The ROC curve showed that the AUC of MHR predicted Korean T2 DM complicated with CAS was 0.644,the P<0.001,the 95% CI was 0.567-0.722,the best critical value was 0.47,the sensitivity was 52.2%,and the specificity was 79.4%,suggesting that MHR has a great predictive value for Korean T2 DM complicated with CAS.11.The ROC curve showed that the AUC of MHR predicted Han T2 DM complicated with CAS was 0.635,the P<0.001,the 95% CI was 0.557-0.712,the best critical value was 0.49,the sensitivity was 36.0%,and the specificity was 87.3%,suggesting that MHR has a great predictive value for Han T2 DM complicated with CAS.Conclusion:1.MHR is the risk factor for CAS of T2 DM patients complicated with CAS in Korean and Han nationality.2.The increase of MHR level may have a great value in predicting T2 DM patients complicated with CAS.3.The MHR level of Korean T2 DM patients with carotid plaque was significantly higher than that of Han. |
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