Clinical Study Chaihu Anshen HuaYu Decoction In Treating Stable Angina Complicated With Mild-to-Moderate Anxiety

Objective:To observe the clinical effect of Chaihu Anshen Hua Yu Decoction on stable angina complicated with mild-to-moderate anxiety.Methods:The subjects of this study were all from the outpatients and inpatients of The Affiliated Hospital of Shandong University of Traditional Chinese Medicine(aged 35-75 years)who were diagnosed with stable angina pectoris complicated with mild anxiety with the syndrome of Qi stagnation blood stasis and heat.The total sample size was 60 cases,and they were randomly divided into experimental group and control group with 30 cases each.The control group was treated with conventional western medicine for stable angina,and the experimental group was treated with Bupleurum Antishen Decoction on the basis of conventional western medicine.The treatment period of both groups was 4 weeks.Heart rate,blood pressure,Seattle Angina Scale(SAQ),Generalized anxiety Scale(GAD-7),Pittsburgh sleep quality Index(PSQI),ecg changes,TCM syndrome score and syndrome efficacy and safety indexes were observed before and after treatment in2 groups.All data were statistically analyzed by SPSS 23.0.Results:After treatment,the experimental group was better than the control group in improving the score of Seattle Angina scale,reducing gad-7 score,reducing Pittsburgh sleep index,improving electrocardiogram and TCM syndrome(P<0.05).Both treatments effectively controlled heart rate and blood pressure.The overall treatment result of experimental group was better than that of control group.There were no obvious abnormalities in liver and kidney functions after treatment,indicating good safety of this study.Conclusion:Chaihu Anshen Hua Yu Decoction can reduce the frequency and degree of angina pectoris in patients with stable angina pectoris combined with mild-to-moderate anxiety(liver stagnation,qi stagnation,phlegm,coagulation and blood stasis type),improve the ecg of patients,effectively relieve the anxiety of patients,improve the quality of sleep.