Clinical Study On The Treatment Of Chronic Coronary Syndrome After PCI(Phlegm And Blood Stasis) With Ditan Quyu Decoction

Objectives:The purpose of this study was to observe the therapeutic effect of Ditan Quyu Decoction in the treatment of chronic coronary syndrome with phlegm and blood stasis after PCI.Methods:Sixty-six patients with phlegm-blood stasis type chronic coronary syndrome after PCI who met the study criteria were randomly divided into control group and treatment group,with 33 cases in each group.The control group was treated with standardized treatment of Western medicine,and the treatment group was treated with Ditan Quyu Decoction on the basis of standardized treatment of western medicine.The course of treatment was 4weeks.The results of traditional Chinese medicine syndrome score,Seattle Angina pectoris scale score,nitroglycerin reduction rate,related serum factors(TC,TG,LDL-C,HDL-C),brachial artery flow-mediated vasodilation function(FMD)and safety index(liver function and kidney function)were recorded before and after treatment.Finally,statistical analysis was used to evaluate the therapeutic effect of Ditan Quyu Decoction in the treatment of chronic coronary syndrome with phlegm and blood stasis after PCI.Results:(1)TCM syndrome score and efficacy:the TCM syndrome score in both groups decreased after treatment compared with that before treatment(P<0.05).The TCM syndrome score of the treated group was lower than that of the control group after treatment(P<0.05),and the overall effective rate of the treated group was higher than that of the control group with87.10% than 68.25%(P<0.05).The results showed that both groups were effective in improving the TCM symptoms,and the treatment group was better than the control group.Nitroglycerin reduction rate efficacy analysis:after treatment,the nitroglycerin reduction rate of 90.32% in the treatment group was higher than that of 68.25% in the control group(P<0.05).(3)Evaluation of Seattle Angina Scale points:all SAQ points in the treatment group increased after treatment compared with those before treatment(P<0.05),and PL,AS,AF and DP in the control group increased compared with those before treatment(P<0.05),and the levels of PL,AS,AF and TS in the treatment group were higher than those in the control group(P<0.05),which were statistically different.(4)Efficacy evaluation of angina pectoris points:the number of angina attacks,the degree of attacks,and the duration of angina pectoris points in the control group and the treatment group decreased compared with those before treatment(P<0.05),and the angina pectoris points in the treatment group were lower than those in the control group(P<0.05),with statistical differences.(5)Analysis of the results of serological related indexes:there was no significant difference in HDL-C levels before and after treatment in the control group(P>0.05),and the levels of TC,TG and LDL-C decreased compared with those before treatment(P<0.05).In the treatment group,TC,TG and LDL-C levels decreased and HDL-C levels increased after treatment compared with those before treatment(P<0.05).And the improvement of TC,LDL-C and HDL-C in the treatment group after treatment was better than that in the control group(P<0.05),which was statistically different.(6)The results of FMD were evaluated that the FMD levels in both groups improved after treatment(P<0.05),and the post-treatment FMD levels in the treatment group were better than those in the control group(P<0.05).(7)There were no abnormal safety indexes in the two groups after treatment.Conclusion:Ditan Quyu Decoction combined with western standardized medicine has more significant therapeutic effect than standardized western medicine in the treatment of chronic coronary syndrome with phlegm and blood stasis after PCI.It can effectively relieve clinical symptoms,regulate blood lipids,improve the diastolic function of brachial artery,and significantly improve the quality of life of patients.