Study On The Correlation Between Postmenopausal Bone Mineral Density And Female Reproductive Clinical Features And Distribution Of Traditional Chinese Medicine Syndromes

Objective: Aiming at the characteristics of postmenopausal osteoporosis(postmenopausal osteoporosis,PMOP)with high incidence,insidious onset,and early prevention,a questionnaire survey was conducted among high-risk groups of PMOP to collect the general condition,physical examination,bone mineral density,estrogen Through data screening and analysis,the correlation between changes in bone mineral density and clinical reproductive characteristics of women after menopause was observed.The research on the distribution of TCM syndromes provides a theoretical basis for the prevention and treatment of postmenopausal osteoporosis with integrated traditional Chinese and Western medicine.The combination of TCM syndrome differentiation and modern medical clinical research will give full play to the advantages of traditional Chinese medicine in the treatment of osteoporosis and improve clinical efficacy.Methods: The research subjects were selected from the Jinan Municipal Hospital,the Osteoporosis Clinic of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,and several communities in Jinan(Yanshan Community,Wendong Community,Shunyu Community),and conducted a questionnaire survey on postmenopausal women aged 50-70,conduct DEXA bone density test and estrogen level test,collect the participants’ TCM syndromes,bone density test results,reproductive characteristics and estrogen indicators and other data,manage and quality control all the collected data,and screen in strict accordance with the inclusion and exclusion criteria Statistical analysis was performed on the collected data using spss22.0 software.Results: 1.Comparison of general data(age,BMI)between normal bone mass group,low bone mass group,osteoporosis group and severe osteoporosis group(hereinafter referred to as four groups): normal bone mass group and osteoporosis group,The age comparison of the severe osteoporosis group was statistically significant(P<0.05),and the age comparison of the low bone mass and osteoporosis group and the severe osteoporosis group was statistically significant(P<0.05).There were significant differences in BMI between the normal mass group and the low bone mass group,osteoporosis group and severe osteoporosis group(P<0.05).2.Comparison of clinical reproductive characteristics(age of menarche,age of menopause,number of pregnancy,breastfeeding time,estrogen level)among four groups of women: normal bone mass group and low bone mass group,osteoporosis group,and severe osteoporosis group.There was a statistically significant difference in age at menarche(P<0.05);there was no significant difference in age at menopause among the four groups(P>0.05),which may be related to the small sample size;the normal bone mass group was associated with osteoporosis There were statistically significant differences in the number of pregnancy between the low bone mass group and the osteoporosis group and the severe osteoporosis group(P<0.05);there was no significant difference in the breastfeeding time among the four groups(P> There was no significant difference in estrogen levels among the four groups(P>0.05),which may be related to the small sample size.3.Combining the osteoporosis group and the severe osteoporosis group,in the study of TCM syndrome types and clinical reproductive characteristics of women,it was found that the number of pregnancies between kidney-yang deficiency syndrome and kidney-yin deficiency syndrome,kidney-yang deficiency syndrome and kidney-essence insufficiency syndrome was significantly higher.The difference was statistically significant(P < 0.05);age at menarche,age at menopause,breastfeeding time,estrogen level and bone mineral density in each part were significantly different in four types: kidney yin deficiency syndrome,kidney yang deficiency syndrome,kidney essence deficiency syndrome and kidney qi deficiency syndrome.There was no statistically significant difference between syndrome types(P>0.05).Conclusion: There is a negative correlation between age and bone mineral density,and a positive correlation between BMI and bone mineral density.In the study of female clinical reproductive characteristics,the age of menarche and the number of pregnancies were related to the occurrence of PMOP.The earlier the age of menarche and the fewer the number of pregnancies,the slower the decrease in bone mineral density after menopause.correlation,possibly due to the small sample size.In the TCM syndrome type research,there is a correlation between the number of pregnancy and the TCM syndrome type,and multiple pregnancy will lead to kidney-yang deficiency;the age of menarche,age of menopause,breastfeeding time,estrogen level,and bone mineral density in each part have no correlation with the TCM syndrome type.,which may be related to the small sample size.