| Objective:This study was conducted to observe the clinical efficacy of the healing solution of Qi Ye Cao,which was developed by our supervisor,professor Shi Rong,on the experienced formula of professor Chen Minfan,a master of Chinese medicine,when applied externally to the postoperative wounds of low-level simple anal fistula with damp-heat infiltration.The purpose of this study is to provide a unique formula with TCM characteristics,easy to use and good clinical efficacy for post-operative anal fistula patients.Methods:Sixty-eight patients who met the inclusion criteria were screened and grouped into 34 cases each in the treatment group and the control group according to the random number table method after surgery for low simple anal fistula with damp-heat injection.The treatment group was treated with topical change of gauze with healing-promoting solution of hepatica and the control group was treated with change of gauze with estaacridine lactate solution.The study was conducted by measuring and recording the wound exudate scores,patient pain scores,and wound healing ratios of the two groups at different time points before(the first postoperative day)and after treatment,following up the final healing time and overall efficacy observation,and summarizing and statistically analyzing the data differences and changes,and finally drawing conclusions.Results:1.A total of 67 cases of this study were finally completed successfully and given the complete study data,and a total of 1 case of shedding was withdrawn from the trial midway.The baseline data such as age,gender,original trauma area,pain score and trauma exudate score before treatment were not statistically different between the two groups and were comparable.2.Overall efficacy observation: On the 28 thpostoperative day,33 patients in the treatment group were cured and 1 case showed efficacy,with a cure rate of 97.06 %;27patients in the control group were cured and 6 cases showed efficacy,with a cure rate of 81.82%.3.Wound healing ratio: The wound healing ratio of both groups increased after treatment.On the 7th,14 th and 28 thpostoperative days,the wound healing ratio was higher in the treatment group,and the difference was statistically significant(P<0.05).4.pain(VAS)scores:(1)On the first postoperative day,there was no significant difference in pain scores between the two groups,and the difference was not statistically significant(P>0.05),which was comparable.On postoperative day 7 and postoperative day 14,the pain scores of the treatment group were lower than those of the control group,and the difference was statistically significant(P<0.05),and the treatment group improved the postoperative trauma pain better than the control group;(2)The pain scores on postoperative day 3 and 7were higher than those on postoperative day 1 in both the treatment and control groups,and the pain scores on postoperative day 7 reached the highest level,and the difference was statistically significant(P<0.05).In both groups,the pain score on the 14 thpostoperative day was lower than that on the 1stpostoperative day,and the difference was statistically significant(P<0.05),and the treatment group was better than the control group.5.Exudate scores:(1)On the first postoperative day,there was no significant difference between the two groups in terms of trauma exudate scores,and the difference was not statistically significant(P>0.05),which was comparable;(2)On the third postoperative day,there was no statistical difference between the two groups in terms of exudate scores(P>0.05);(3)On the seventh postoperative day and the fourteenth postoperative day,the treatment group had lower exudate scores than the control group,and the difference was statistically significant(P<0.05).6.Wound healing time: the average healing time of patients in the treatment group was24.95 days,and the average healing time of patients in the control group was 29.06 days,the difference was statistically significant(P<0.05),and the long-term healing of the treatment group was significantly better than that of the control group.Conclusion:1,Based on the academic thought of National Medical Masterprof.Chen Minfan,the empirical formula Qi Ye Cao promoting Healing Solution for the topical treatment of damp-heat-infused low simple anal fistula has quite good clinical effects and has the advantages of early onset of action,short healing time and high overall efficacy compared with the surgical replacement of Ethacridine lactate,as well as significantly improving the characteristics of the patient’s pain condition and wound exudation and significantly improving the patient’s postoperative quality of life.2.professor Shi Rong,the supervisor,has inherited the academic thought of professor Chen Minfan,the master of national medicine,and the experienced formula of Qi Ye Cao promote Healing Liquid is a surgical treatment with safe and significant clinical efficacy.No significant side effects and adverse reactions were observed during the use of the drug,and the safety is good,which is worthy of further study and promotion in clinical practice. |
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