Effect Analysis Of Mother-to-child Blocking Of Hepatitis B Virus And Investigation Of Hepatitis B Infection Status And Influencing Factors In Children

Objective:To investigate the effect of mother-to-child blocking of hepatitis B virus(HBV)and the status and influencing factors of HBV infection in children,and to provide reference for the prevention and control of HBV serological infection in preschool children in this area in the futureMethod:From January 2019 to December 2019,a total of 3325 preschoolers who came to our hospital for physical examination were selected by multi-stage random sampling method,and 3266 preschoolers were finally included as research objects after excluding invalid data.The guardian of the study under the condition of informed consent and voluntary,collected on an empty stomach peripheral venous blood,using enzyme-linked immunosorbent assay for all research object infection status of HBV serological test,at the same time extend self-made questionnaires to collect children’s demographic characteristics,HBV exposure history,history of hepatitis b vaccination,and maternal and child block etc.Neonatal Hep B+HBIG injection after birth was in group P1,neonatal Hep B+HBIG injection after birth was in group P2,neonatal Hep B+HBIG injection after birth was in group P3,and neonatal Hep B+HBIG injection after birth was in group C without mother-to-child blocking.After all the data were recorded and checked correctly,univariate and multivariate Logistic regression analysis was performed on the influencing factors of HBV serological infection.Result:1.Among 3266 preschoolers,128 cases(3.9%)were HBs Ag positive.Among400 HBs Ag positive children,377(94.25%)received mother-to-child blocking,32(8.49%)of which were HBs Ag positive.Among the 23 children who did not receive mother-to-child block,20(86.96%)were HBs Ag positive.2.Compared with group C,the positive infection rate of preschool children born to mothers in groups P1,P2 and P3 was significantly lower(P<0.05);Compared with P1 group,the positive infection rate of preschool children born to mothers in P2and P3 groups was significantly lower(P<0.05).Compared with P2 group,positive infection rate of preschool children born to mothers in P3 group was significantly lower(P<0.05).3.Compared with group C,the decrease of HBs Ag,HBe Ag and HBV DNA of mothers in groups P1,P2 and P3 from baseline was statistically significant(P<0.05).Compared with P1 group,the decrease of HBs Ag,HBe Ag and HBV DNA in P2 and P3 groups from baseline was statistically significant(P<0.05).Compared with P2group,the decrease of HBs Ag,HBe Ag and HBV DNA in P3 group from baseline was statistically significant(P<0.05).4.The success rate of mother-to-child occlusion was lower in HBe Ag positive mothers than in HBe Ag negative mothers(P<0.05).Maternal HBV DNA>10~6IU/ml was lower than maternal HBV DNA≤10~6IU/ml(P<0.05).Abnormal ALT and AST had lower success rate than normal ALT and AST(P<0.05).5.Compared with group C,the positive infection rate of breast-fed preschool children in groups P1,P2 and P3 was significantly lower(P<0.05);Compared with P1 group,the positive infection rate of preschoolers in P2 and P3 groups who were breast-fed was significantly lower(P<0.05).Compared with P2 group,positive infection rate of preschool children in P3 group who were breast-fed was significantly lower(P<0.05).6.Multivariate Logistic regression analysis showed that residence(rural area)(OR:1.777,95%CI:1.420-2.134),oral diagnosis and treatment history(OR:1.973,95%CI:1.638-2.308)and traumatic treatment history(OR:2.176,95%CI:1.802-2.550)was an independent risk factor for HBV serological infection in preschool children(P<0.05),while Hep B qualified vaccination(OR:0.289,95%CI:0.118-0.517),Hep B full vaccination(OR:0.376,95%CI:0.219-0.631)And mother-to-child blocking(OR:0.326,95%CI:0.201-0.615)were protective factors for HBV serological infection in preschool children(P<0.05).Conclusion:The antiviral treatment of mothers receiving tenofovir during pregnancy and newborns receiving Hep B+HBIG after birth has a significant effect.This survey showed that the HBV infection rate of preschool children was 3.9%,and the living area,the history of oral diagnosis and treatment,the history of traumatic treatment,the status of Hep B vaccination and mother-to-child blocking were all influential factors for HBV serological infection of preschool children.