Association Between Biomarkers And Incidence Of Preoperative Deep Vein Thrombosis(DVT)after Tibial Fracture

Objective:The aim of this study was to discover the correlation between blood biological indicators and the occurrence of DVT before surgery for traumatic tibial fractures.Methods:Data were collected and retrospectively analyzed from patients admitted for tibial fractures(including: tibial plateau fractures,tibial stem fractures,pilon fractures)and underwent orthopedic surgery between January 1,2020 and December 31,2020 in the trauma department.Bilateral lower extremity arteriovenous ultrasound reclassification was used to screen for preoperative bilateral lower extremity DVT.Collect biomarkers before admission for anticoagulation treatment: serum total protein(TP),white blood serum protein(ALB),serum alanine aminotransferase(ALT),serum aspartate aminotransferase(AST),serum total bilirubin(TBIL),white blood cell count(WBC),hemoglobin(HGB),platelets(PLT),absolute neutrophil(NEU),absolute lymphocyte(LYM),fibrinogen(FIB),D-dimer,and fibrinogen degradation product(FDP).Univariate and multivariate logistic regression analyses were performed to identify independent risk factors,and the predictive value of biological markers associated with DVT was measured using subject operating curve(ROC)analysis and area under the curve(AUC).Results:Among the 144 patients included,22.2% had preoperative DVT.Three factors were determined to be significantly related to DVT,including serum total protein(TP),Ddimer and fibrinogen degradation products(FDP).Serum total protein(TP),D-dimer and fibrinogen degradation products(FDP)are independently related to DVT,in which the area under the curve,sensitivity and specificity of FDP are respectively;0.76,75,74.11.The results show that high-level FDP has good predictive value for DVT.Conclusion:FDP facilitates the initial screening,individualized risk assessment,and risk classification of patients at risk for DVT,leading to the development of targeted prevention programs.