Explore Professor Liu Zhaoxia’s Medication Rules And Experience Summary In The Treatment Of IBS-D Based On Data Mining

Objective:Using data mining technology to explore medication rules of Professor Liu Zhaoxia in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D),and summarize her clinical experience.Methods:First of all,we collected and sorted out the medical records of patients with IBS-D treated by Professor Liu Zhaoxia in Liver,Spleen and Stomach Diseases Department at The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from September 2018 to September 2021.Screened all cases strictly according to inclusion and exclusion criteria,and determine the efficacy of cases that meet the criteria,eventually 213 effective cases were included to establish the database.Secondly,with the help of Frequency statistics,association rule analysis,cluster analysis and other methods the relevant data of medical records and medication rules were analyzed.Finally,combined with follow-up study,the experience of Professor Liu Zhaoxia were extracted from the results of data mining.Results:1.Efficacy evaluation:After four weeks treatment,the IBS-SSS score and the total TCM syndrome score decreased significantly,with statistically significant difference(P<0.01).After treatment,24 cases were cured,112 cases were significantly effective,77 cases were effective,19 cases were ineffective,and the total effective rate was 91.81%.2.General information:A total of 213 effective cases were included,there were 114 males and 99 females.Age distribution is concentrated in the 18-49 age group,accounting for 69.48%.3.TCM syndrome type and the information of four diagnoses:Among TCM syndrome types,liver depression and spleen deficiency syndrome(43.19%)and spleen deficiency dampness syndrome(35.68%)appeared in high frequency.The top five symptoms were diarrhea,abdominal distension,sleeplessness,abdominal pain and loss of appetite.The tongue texture was mainly light red tongue,red tongue and dark red tongue.The coating on tongue was mainly white,thin yellow and White slippery.The pulse was mainly stringy pulse,thin pulse and smooth pulse.4.Prescription and medication rules:A total of 130 drugs were involved in213 prescriptions.Twelve drugs with the highest frequency were coix seed,poria cocos,yam,tangerine peel,bupleurum,astragalus membranaceus,codonopsis pilosula,aucklanoides,magnolia officinalis,coptis chinense,fructus aurantii and ginger pinellia.Which consistent with the drugs obtained by association rule analysis,were the core drugs for the treatment of IBS-D.According to statistics,there were 16 kinds of drug efficacy,the most commonly used drugs were tonifying drugs,followed by qi-regulating drugs,clearing damp and promoting diuresis drugs,damp-resolving drugs.The medicinal property is mainly warm and flat.The medicinal taste is mainly xin,sweet and bitter.The return to meridian is mainly spleen,stomach,lung and liver.46 drug association rules were obtained,and six commonly used drug combinations were obtained by cluster analysis of high-frequency drugs.5.Drug syndrome rules:The combination of common symptoms and commonly used drugs for five syndrome types were obtained through association rule analysis.Conclusion:1.In the treatment of IBS-D,Professor Liu Zhaoxia mainly uses the drugs with warm and flat nature,spicy,sweet and bitter taste,belong to the spleen,stomach,lung and liver meridian.The core drugs include coix seed,poria cocos,yam,tangerine peel,bupleurum,astragalus membranaceus,codonopsis pilosula,aucklanoides,magnolia officinalis,coptis chinense,fructus aurantii and ginger pinellia.2.Professor Liu Zhaoxia believes that the basic pathogenesis of IBS-D are spleen deficiency and dampness,liver stagnation and qi stagnation.The principles and methods include invigorating qi and spleen,securing the root and supplementing yuan;clearing damp and promoting diuresis,combining tonify and dredge;promoting the circulation of qi and resolving depression,regulating the liver and spleen simultaneously.Medication and treatment features include use mild drugs;careful use of solid astringent drugs,regard dredge as tonify;pay attention to qi and relieve emotions;take care of the spleen and stomach to prevent recurrence.