Clinical Research Of Phlegm-heat Clearing And Panting-calming Formula In The Treatment Of AECB With Phlegm-Heat Obstructing Lung Syndrome

ObjectiveChronic bronchitis(CB)is a common respiratory disease,mainly due to infection or non-infectious factors caused by chronic non-specific inflammatory response.Chronic bronchitis is usually a long course of disease which difficult to heal,and infection,weather changes or allergens are likely to cause acute exacerbation of chronic bronchitis(ECB).Although Western medicine is more effective in treating the disease,treatment often fails to achieve the desired results due to the increasing number of drug-resistant bacteria and the high number of adverse reactions and allergic reactions to Western drugs.In recent years,although new antibacterial drugs are emerging,the number of drug-resistant species is increasing year by year.Compared with western medicine,Chinese patent medicines have good broad-spectrum anti-infection,cough suppressing,phlegm resolving and asthma calming effects,and they have stable effects with few side effects.In this thesis,we studied the clinical efficacy and safety of Phlegm-Heat clearing and Panting-calming Formula in the treatment of acute exacerbation of phlegm-heat and lung type chronic bronchitis through a randomized controlled trial.MethodsAll cases were obtained from patients with acute exacerbation of chronic bronchitis attending the Department of Pulmonary Diseases,Wuqing Hospital of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,from January 2021 to January2022.After sample size estimation,66 patients with acute exacerbation of chronic bronchitis with phlegm-heat stagnation in the lungs who met the inclusion criteria were randomly divided into 2 groups,the control group and the treatment group,with 33 cases in each group,and finally 30 cases in the control group and 30 cases in the treatment group met the criteria in total.Both the control group and the treatment group were given conventional western medical treatment for the disease,such as infection control,cough suppression and expectoration.The control group was given Phlegm-Heat clearing and Panting-calming Formula on this basis.The indexes of the patients before and after treatment were recorded and the treatment effect was evaluated by SPSS statistics 26 software.The measurement data were expressed as mean±standard deviation((?)±s)using t-test;for rank data,a non-parametric test was performed:the count data were tested by chi-squarex~2andP≤0.05representing a significant difference.Results(1)The differences in the length of disease,gender,age,leukocyte level,percentage of neutrophils,C-reactive protein CRP content,and total TCM evidence score between the two groups were not significant and comparable(P>0.05).(2)Compared with the control group,the total effective rate and apparent control rate of disease efficacy were significantly higher in the treatment group than in the control group(P≤0.01).(3)Comparison of the efficacy of signs and symptoms:the improvement of cough, coughing sputum,wheezing and rales was significant in both groups after treatment,and the treatment effect of coughing sputum and cough was significantly higher in the treatment group than in the control group(P≤0.01),but there was no significant difference in the improvement of lung rales and wheezing.(4)Comparison of total TCM syndrome points:both groups showed significant improvement(P<0.01),but the effect of the treatment group was more significant in improving the total TCM syndrome points(P<0.05).(5)Comparison of total white blood cell(WBC)conditions:both groups were able to significantly reduce WBC(P≤0.01),and there was no significant difference in the treatment effect between the two groups.(6)Comparison of neutrophil percentage(Neut%):Both groups were able to significantly reduce Neut%,and there was no significant difference in the treatment effect between the two groups.(7)C-reactive protein:C-reactive protein was significantly reduced between the two groups,and there was no significant difference in the therapeutic effect between the two groups.(8)No significant abnormalities were found in safety indexes such as liver and kidney function,urine and stool routine before and after treatment in the two groups(P>0.05)ConclusionPhlegm-Heat clearing and Panting-calming Formula is more effective in the treatment of phlegm-heat depression evidence of chronic bronchitis,which can reduce the duration of symptoms such as coughing,coughing,phlegm and asthma,improve the Chinese medical symptoms of patients,increase the clinical cure rate and efficiency,without significant adverse reactions,and has high clinical application value.