Observation Of Clinical Efficacy Of "Nourishing Yin And Removing Blood Stasis Method" In The Treatment Of MDR-TB Patients With Yin Deficiency And Blood Stasis

Objective To observe the clinical curative effect of "Nourishing Yin and Removing Blood Stasis" Chinese herbal medicine Kanglao Mixture on multidrug-resistant pulmonary tuberculosis patients with yin deficiency and blood stasis type.Methods Collected 60 cases of multidrug-resistant pulmonary tuberculosis patients with Yin deficiency and blood stasis syndrome from January 2018 to July 2021 in Lishui Traditional Chinese Medicine Hospital.The tested patients were randomly assigned to the control group(group A)and the observation group(group B),with 30 patients in each group according to the ratio of 1:1.The control group was treated with western medicine chemotherapy alone,and the observation group was treated with western medicine chemotherapy plus Kanglao Mixture based on the method of "Nourishing Yin and Removing Blood Stasis".The chemotherapy regimen was 6ZKm(Am,Cm)Lfx(Mfx)Cs(PAS,E)Pto/18ZLfx(Mfx)Cs(PAS,E)Pto.Observed two groups of patients before and after treatment of TCM symptom scores,sputum bacteria negative conversion,lung CT examination of lesions absorption,and adverse reactions.Results 1.There was no statistical significance in the comparison of TCM syndrome scores between the two groups before treatment(P>0.05);After completing the 6-month intensive treatment,the TCM syndrome scores of the two groups decreased,and the improvement degree of the observation group was significantly better than that of the control group,and the difference was statistically significant.(P<0.05)2.There was no significant difference in the negative conversion rate of Mycobacterium tuberculosis between the two groups at the end of 2 months of treatment(P>0.05);At the end of 5 months of treatment,the negative conversion rate of Mycobacterium tuberculosis in the observation group was 69.0%,which was higher than 42.9%in the control group,and the difference was statistically significant(P<0.05);At the end of 6 months of treatment,the negative conversion rate of Mycobacterium tuberculosis in the observation group was 82.8%,which was higher than 57.1%in the control group,and the difference was statistically significant(P<0.05).3.At the end of 6 months of treatment,the absorption of lesions in the two groups was examined by lung CT imaging.The effective rate in the observation group was 65.5%,which was significantly higher than that in the control group,which was 39.3%,and the difference was statistically significant(P<0.05).4.During the treatment,the number of people with leukopenia in the observation group was significantly less than that in the control group,and the difference was statistically significant(P<0.05).The number of people with impaired liver function in the observation group was less than that in the control group,but there was no statistical significance(P>0.05).The number of people with gastrointestinal reactions in the observation group was significantly less than that in the control group,and the difference was statistically significant(P<0.05).5.In terms of treatment outcome,the cure rate of the observation group was higher than that of the control group,with statistical difference(P<0.05).Conclusion 1."Nourishing Yin and Removing Blood Stasis" Traditional Chinese Medicine Preparation Kang lao Mixture Combined with Chemotherapy and Western Medicine in the Treatment of Multidrug-resistant Tuberculosis Patients with Yin Deficiency and Blood Stasis Syndrome,can more significantly improve the clinical symptoms of the patients and reduce the TCM symptom score,significantly shorten the time of sputum culture turning to negative,increase sputum bacteria to negative rate,and accelerate the absorption of lung lesions,improve the clinical cure rate.2."Nourishing Yin and Removing Blood Stasis" Chinese herbal preparations,the modified anti-tuberculosis mixture combined with chemotherapy and western medicine can significantly reduce the incidence of adverse drug reactions such as leukopenia and gastrointestinal discomfort in patients with multidrug-resistant tuberculosis with yin deficiency and blood stasis syndrome.Deficiency and blood stasis type multidrug-resistant pulmonary tuberculosis have an attenuating effect.