| Objective: To investigate the relationship between the theory of kidney deficiency and phlegm-stasis and postcirculation ischemic vertigo by observing the clinical efficacy and safety of self-designed tonifying kidney and phlegm-stasis in the treatment of postcirculation ischemic vertigo of patients with kidney deficiency and phlegm-stasis.To provide data support for the application of tonifying kidney phlegm Tongluo Dingxuan decoction.Content: To analyze the clinical efficacy and safety of self-designed Busshen Huatan Tongluo Dingxuan Decoction by observing and recording the TCM syndrome accumulation table,vertigo disorder score table(DHI),meridian Doppler(TCD)observation index data and adverse reactions of patients with postcirculation ischemic vertigo.Methods: According to inclusion and exclusion criteria,70 eligible patients were randomly divided into control group and treatment group,with35 patients in each group.The treatment group was given 5mg flunarizine hydrochloride capsules(Xi ’an Jansen Pharmaceutical Co.,LTD.,National medicine approval number H10930003 5mg/ capsule)before going to bed,and was given self-prepared tonifying kidney phlegm Tongluo Dingxuan decoction in the morning and evening,and the control group was given 5mg Flunarizine hydrochloride capsules before going to bed.All patients with underlying diseases received routine treatment for underlying diseases.Both groups were observed for 2 weeks.Average blood flow velocity(Vm),vascular pulsation index(PI),vertigo disorder scale(DHI),TCM syndrome score scale and other indicators of both vertebral artery(VA)and basilar artery(BA)were collected and recorded before treatment and 14 days after treatment.Whether there were adverse reactions was recorded,adverse reaction report was written,and the data results were statistically analyzed.During the treatment,1patient in the control group withdrew from the study due to refusal of relevant examinations,and 1 patient in the treatment group was excluded due to self-administration of other vertigo drugs.A total of 68 patients successfully completed the clinical trial,with 34 patients in each group.Results: 1.Comparison of general conditions: The age,gender,basic diseases and other data of the two groups were tested by SPSS software,and there was no significant difference.2.Before treatment,there were no significant differences in TCM syndrome scores,vertigo scale scores and transcranial Doppler observation indexes between the two groups(P > 0.05),which could be compared.3.Vertigo disorder scale: The scores before and after treatment of the two groups were compared respectively within the group,and the results showed that the scores were decreased compared with those before treatment(P < 0.05).In addition,the two groups were compared between the two groups,P < 0.05,the difference was significant,the treatment group was significantly higher than the control group.4.Transcranial Doppler(TCD)results: Intra-group comparison was made between the two groups respectively before treatment,and all indicators of TCD in the two groups were improved after treatment(P < 0.05);An intergroup comparison between the two groups showed that the improvement in the treatment group was better than that in the control group(P < 0.05).5.Comparison of TCM syndrome scores: Before and after treatment scores of patients in the two groups were compared within the group,and it was found that TCM syndrome scores of patients in the two groups were lower than before(P < 0.05).Between the two groups,the results showed that the treatment group was better than the control group(P < 0.05).6.Comparison of clinical efficacy: the overall effective rate of the treatment group was 94.12%,and that of the control group was 79.41%.The rank sum test showed that the difference was significant,P = 0.034,P < 0.05,and the therapeutic effect of the treatment group was significantly superior to the control group.Conclusions: 1.The effect of self-prepared Bushen-huatan-Tongluo Dingxuan decoction combined with Fluunrizine hydrochloride capsule in the treatment of patients with post-circulation ischemic vertigo of renal deficiency,phlegm-stasis blocking collateral-collateral type is obviously superior to that of western medicine alone,which can effectively improve blood flow dynamics,effectively reduce patients’ TCM syndrome score and vertigo disorder scale score,and effectively reduce patients’ clinical discomfort symptoms and psychological pressure.Improve patients’ social adaptability.2.The clinical safety of self-prepared Tonifying kidney phlegm Tongluo Dingxuan decoction is high,and no adverse reactions occur during the treatment. |
PDF Full Text Request