Observation On Curative Effect Of Self-made Wenyang Bushen Decoction In Treatment Of Elderly Primary Osteoporosis With Kidney-Yang Deficiency Syndrome

Objective:To observe the clinical efficacy of self-made Wenyang Bushen Decoction in treating senile primary osteoporosis with kidney-yang deficiency.Methods:From October 2020 to April 2022,80 elderly patients with primary osteoporosis of kidney-yang deficiency who met the inclusion and exclusion criteria,visited the endocrinology clinic and ward of Weifang Hospital of Traditional Chinese Medicine were selected.They were numbered according to the order of treatment,and then grouped by random number table method,with 40 cases in each treatment group and control group.The control group was treated with alfacalcidol soft capsules and calcium carbonate D3 tablets and other general treatments.The treatment group was given non-decocted granules made from self-made Wenyang Bushen Decoction on the basis of the control group,and the treatment continued for 3 months.Bone pain scores and traditional Chinese medicine syndrome scores,bone mineral density,bone metabolism-related indicators detection and safety data were evaluated before and after treatment in the group.Results:After treatment,the bone pain scores and TCM syndrome scores of the two groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).The syndrome score was lower than that of the control group,and the difference was statistically significant(P<0.05).The improvement degree of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).Compared with the density comparison,there was no statistically significant difference between the treatment group and the control group(P>0.05).After treatment,the bone metabolism indexes in the two groups were significantly improved compared with those before treatment,and the difference was statistically significant(P<0.05).After comparison,the difference was not statistically significant(P>0.05),no serious adverse reactions occurred in the two groups,and there was no statistically significant difference in safety indicators(P>0.05).Conclusion:Self-made Wenyang Bushen Decoction can significantly relieve bone pain and improve clinical symptoms in elderly patients with kidney-yang deficiency type osteoporosis,and can regulate bone metabolism.It is safe and effective,and is worthy of further study.Compared with Western medicine,Wenyang Bushen Decoction can significantly improve TCM syndromes and relieve bone pain.There is no significant difference between the two in terms of increasing bone density and improving bone metabolism.