| Objective The purpose of this study is to observe the clinical efficacy of Dahuang Fuzi Decoction plus acupuncture and moxibustion in treating patients with cancerous incomplete intestinal obstruction of spleen deficiency and cold accumulation type,and to explore the mechanism,effectiveness and safety of this treatment.Methods From October 2020 to October 2022.10,60 inpatients who were diagnosed as incomplete completeness intestinal obstruction(spleen deficiency and cold accumulation)in the Third Department of Cancer,Weifang Hospital of Traditional Chinese Medicine,met the inclusion and exclusion criteria,voluntarily participated in the test and signed the informed consent form.The control group received routine Western medicine support treatment: fasting,controlling gastrointestinal pressure,correcting electrolytes,improving acid-base imbalance,anti infection,nutritional support,pain relief,and other related symptomatic support treatments.On this basis,the experimental group was treated with acupuncture at the lower confluence points(Shangjuxu,Zusanli,Xiajuxu)of the Hand Yangming Large Intestine Meridian,Foot Yangming Stomach Meridian,and Hand Taiyang Small Intestine Meridian,combined with oral administration of Dahuang Fuzi Tang.The treatment period was 7 days.Main observation indicators:(1)Symptom relief time of nausea,vomiting,abdominal pain,and bloating,average length of hospital stay,first time of exhaust,defecation time,and time to consume solid food;(2)Traditional Chinese medicine symptom score;(3)qql score;(4)KPS score;(5)Overall effective rate of treatment;(5)Positive rate of imaging after treatment,observation and statistical analysis,and conclusion drawn.Result The results showed that there was no statistically significant difference in gender,age,age distribution,primary disease status,tumor type,imaging data,and albumin distribution level at enrollment between the two groups of patients.Baseline result analysis: Comparing the gender,age,tumor type,course of disease,nutritional status,and albumin distribution level at enrollment of the included patients showed no statistically significant differences(P>0.05).Subjective efficacy analysis: The treatment group significantly shortened the time for first exhaust,first defecation,and first solid food consumption compared to the control group,and the difference was statistically significant.Comparing the seven symptom scores of abdominal pain,bloating,exhaust,defecation,nausea,vomiting,and bowel sound hyperactivity between the two groups after treatment,the results showed that the scores of the two groups of patients after treatment were significantly reduced compared to before treatment,and had statistical significance.Compared between groups,except for the symptom of nausea,the scores of the other six symptoms in the treatment group were significantly lower than those in the control group(P<0.05).Objective indicator analysis: The symptom score and efficacy evaluation(effective rate)of patients before and after treatment were compared using t-test and rank sum test,respectively.The results showed significant statistical differences(P<0.05).KPS score and QQL-100scale: Before treatment,there was no statistically significant difference in both scores between the two groups of patients(P>0.05).After treatment,the KPS and QOL-100 scores of the treatment group were significantly higher than those of the control group,with a statistically significant difference(P<0.05).Total effective rate: After treatment,the total effective rate of the treatment group was 90.00%,while the total effective rate of the control group was 60.00%,with a statistically significant difference(P<0.05).In terms of safety: None of the patients in the treatment group experienced serious adverse reactions during the treatment process,with only two patients experiencing needle sickness,no lifethreatening symptoms,and improved after rest.In the control group,one patient experienced angina pectoris and one patient experienced wheezing,which improved after targeted treatment.Both groups continued to successfully complete the treatment.Conclusion The combination of modified Dahuang Fuzi Tang and acupuncture in the treatment of malignant intestinal obstruction can effectively improve symptoms such as abdominal pain,bloating,nausea,vomiting,shorten the first time of defecation,as well as the time of eating,thereby shortening the hospitalization time.At the same time,it can significantly improve the patient’s quality of life score and traditional Chinese medicine symptom score.Compared with before treatment,the imaging results also showed positive results,and the incidence of adverse reactions is low,safe,economical,and green Quick to take effect.Confirmed based on the treatment principles of warming and tonifying the spleen and kidney,promoting blood circulation and resolving stasis,the combination of modified Dahuang Fuzi Tang and acupuncture is an effective method for treating malignant intestinal obstruction,safe and reliable,and worthy of clinical promotion and use. |
PDF Full Text Request