Research On Drug Use Law Of Clinical Syndrome Differentiat Ion In Treatment Of Non-Alcoholic Fatty Liver In Rizhao Hospital Of Traditional Chinese Medicine Based On Data Mining

Objective: Through retrospective analysis of the clinical data of patients with non-alcoholic fatty liver disease in Rizhao Hospital of Traditional Chinese Medicine in the past 10 years,to explore the law of drug use in clinical differentiation and treatment of non-alcoholic fatty liver disease in Rizhao Hospital of Traditional Chinese Medicine.Method: A total of 253 inpatient and outpatient medical records diagnosed as non-alcoholic fatty liver disease from January 2013 to December 2022 were collected using the medical record retrieval system of Rizhao Hospital of Traditional Chinese Medicine.After standardized processing of the syndrome types and TCM related information,a database was established.Data mining and statistical correlation analysis were carried out by using software such as office Excel 2019,IBM SPSS Statistics26 system SPSS Modeler and traditional Chinese medicine inheritance calculation platform,so as to find out the medication rules for the treatment of non-alcoholic fatty liver disease in Rizhao Hospital of Traditional Chinese Medicine.Results: According to the results of this study,22 TCM syndrome types were identified in the process of syndrome differentiation in the treatment of NAFLD in Rizhao Hospital of Traditional Chinese Medicine,among which4 high-frequency syndromes occurred more than 10 times,namely,syndrome of dampness-heat,syndrome of liver depression and spleen deficiency,syndrome of liver stagnation of Qi and syndrome of qi stagnation and blood stasis.The most kinds of drugs were heat-clearing drugs,followed by water-clearing drugs and tonifying drugs.Among 209 Chinese herbs,poria was the most common,followed by licorice,bupleurum,atractylodes,paeony and tangerine peel.The properties of commonly used drugs are mainly cold,followed by warm and flat,bitter,sweet and xin,and spleen,lung,liver and stomach channels.The most commonly used treatment method is clearing heat and dampness,followed by soothing the liver and spleen,soothing the liver and regulating qi,and then removing phlegm and dampness.In the study on compatibility of traditional Chinese medicine,cluster analysis divided high-frequency traditional Chinese medicine into 4 categories,forming 4 new prescriptions,whose effects were as follows:(1)clearing heat and dampness,activating blood and regulating qi,(2)strengthening spleen and regulating dampness,(3)regulating qi and phlegm,clearing heat and dampness,cooling blood and promoting blood circulation,(4)soothing liver and relieving depression,nourishing blood and promoting blood circulation,regulating qi and stomach;Factor analysis divided related drugs into 8 groups,each group of Chinese medicines reflected the treatment methods of soothing the liver and promoting qi and blood,clearing heat and dampness,soothing the liver and nourishing the blood,clearing heat and detoxifying,strengthening the spleen and eliminating phlegm,clearing heat and eliminating phlegm,etc.Association rules analysis commonly used medicine to treatment the disease: sweet attached and rhizoma chuanxiong,radix bupleuri,incense,orange-radix bupleuri,attached the attached,radix paeoniae alba,radix bupleuri,incense,dried tangerine or orange peel-radix bupleuri,pinellia,atractylodes poria cocos,rhizoma corydalis,radix paeoniae alba,radix bupleuri,lotus leaf,atractylodes poria cocos,bitter orange,tangerine peel-radix bupleuri;Finally,logistics regression analysis was conducted to study the high correlation of 4 high frequency syndrome types of TCM,and it was found that the high correlation drugs of the syndromes of dampness and heat were Radix baicalensis,Yinchen,Trichotonia Chuanqin,Fructus plantagliae,Forsythia,coix seed,Pogostemon,gardenia,and bupleurum,pinellia pinellia,poria cosi,Paeoniae alba,Trichosanthus.Liver-qi stagnation syndromes were Fructus aurantii,Fructus aurantii,gardenia,tangerine peel and glycyrrhiza.Qi stagnation and blood stasis syndromes are angelica sinensis,cortex moutan and Ligusticum Chuanxiong.Conclusion: Through the mining and analysis of the data of the past medical records,the medication rules of the clinical differentiation and treatment of non-alcoholic fatty liver disease in Rizhao Hospital of Traditional Chinese Medicine were obtained,and the pathological nature of non-alcoholic fatty liver disease was generally characterized by deficiency of the essence and deficiency of dampness and heat,qi stagnation,phlegm turbidity,blood stasis,etc.The deficiency of the essence was most common with spleen deficiency.Therefore,the treatment was based on the principle of removing the evil and strengthening the spleen,besides strengthening the spleen and strengthening the essence.Clearing heat and dampness,qi and phlegm,activating blood circulation and removing blood stasis are commonly used to remove evil.Hope to provide ideas for clinical prescription drug use.