Clinical Efficacy Of Shugan Ningxin Decoction In The Treatment Of Ventricular Premature Contraction With Liver Depression And Qi Stagnation Type

Objective: To observe the clinical efficacy and safety of Shugan Ningxin Decoction in the Treatment of Ventricular Premature Contraction with Liver Depression and Qi Stagnation Type,in order to to broaden new ideas in the treatment of premature ventricular contraction in Chinese medicine.Methods: From June 2021 to December 2022,64 patients with premature ventricular contractions meeting the inclusion criteria of liver depression and qi stagnation evidence were selected from the the second department of north city Internal Medicine,Linyi Hospital of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine outpatient clinic and ward.64 patients were randomly divided into 32 cases in the test group and 32 cases in the control group according to the randomized control principle using the random number table method and the envelope method.The control group was treated with basic lifestyle modification and oral mexiletine hydrochloride tablets,and in the test group,Shugan Ningxin Decoction were given on top of the mecillin hydrochloride tablets.After 4 weeks of treatment,patients were observed for changes in the number of premature ventricular beats on 24 h ECG,Lown grade,heart rate variability analysis and TCM syndrome score before and after treatment,importing data into SPSS 26.0 for analysis.Results: 1.Comparison of total scores of TCM syndromes and efficacy:After treatment,the total scores of TCM syndromes in both groups decreased,and the differences were statistically significant(P<0.05).The experimental group decreased more significantly than the control group,and the difference was statistically significant(P<0.05).The effective rate of improving TCM syndromes in the experimental group was 83.33%,and the effective rate of improving TCM syndromes in the control group was60.00%;2.Comparison of individual TCM syndrome scores:The scores of individual TCM syndromes in the experimental group were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the two individual syndromes of palpitation and chest and abdomen fullness in the control group were lower than those before treatment.The difference was statistically significant(P<0.05).There was no significant decrease in the four individual syndromes of chest tightness,flank pain,irritability and good sighing in the control group,and the difference was not statistically significant(P>0.05).In improving the individual syndromes of patients,the treatment effect of the experimental group was significantly better than that of the control group,and the difference was statistically significant(P<0.05);3.Comparison of the number of ventricular premature beats in 24-hour dynamic electrocardiogram and the reduction of the number of ventricular premature beats in 24 hours:After treatment,the number of ventricular premature beats in 24-hour dynamic electrocardiogram of the two groups decreased compared with that before treatment,and the difference was statistically significant(P<0.05),and the experimental group decreased more significantly than the control group,the difference was statistically significant(P<0.05).The effective rate of reducing the number of ventricular premature beats in 24 hours in the experimental group was 93.33%,and the effective rate of reducing the number of ventricular premature beats in 24 hours in the control group was 60.00%;4.Comparison of ventricular Lown classification and curative effect:After treatment,the ventricular Lown classification of the two groups was significantly improved compared with that before treatment,and the difference was statistically significant(P <0.05).The improvement of ventricular Lown classification in the experimental group was more obvious than that in the control group,and the difference was statistically significant(P<0.05).The effective rate of improving ventricular Lown classification in the experimental group was 60.00%,and the effective rate of improving ventricular Lown classification in the control group was 83.33%;5.Comparison of heart rate variability indexes:After treatment,the heart rate variability indexes of the two groups were significantly improved compared with those before treatment,and the differences were statistically significant(P<0.05).The improvement of heart rate variability in the experimental group was more obvious than that in the control group,and the difference was statistically significant(P<0.05);6.Comparison of safety indicators:There were no obvious adverse reactions during the treatment of the two groups of patients,and there were no obvious abnormal changes in the safety indicators before and after treatment,indicating that the treatment methods of the two groups were safe.Conclusion: The efficacy of Shugan Ningxin Decoction combine with mecillin hydrochloride tablets in treating ventricular premature beats with liver depression and qi stagnation was better than that of mecillin hydrochloride tablets alone in reducing the number of ventricular premature beats,lowering the Lown grade and Chinese medicine syndrome score,and improving heart rate variability,without increasing the safety risk.