| Objective: To explore the clinical efficacy and advantages of chemotherapy-related oral mucositis,especially oral mucositis caused by 5-fluorouracil,by analyzing the effect of odorized red scatter on chemotherapy-related oral mucositis,in order to provide relevant clinical evidence for the combination of traditional Chinese and Western medicine in the treatment of chemotherapy-related oral mucositis.Methods: 60 patients who met the inclusion and exclusion criteria were randomly divided into control group(n=30)and treatment group(n=30).All patients were treated with 5-fluorouracil-related chemotherapy.The drug was used within 24 hours after the diagnosis of oral ulcer after chemotherapy,and the control group was given Kangfuxin liquid gargle and swallowing.On this basis,the treatment group combined with Jiawei Daochi Powder gargled and swallowed.After continuous treatment for 7 days,the changes of oral mucositis grade,pain score,ulcer diameter,number of ulcers and TCM syndrome scores were observed and statistically analyzed before and after treatment.Results:(1)There were no shedding cases among the 60 patients included in the trial.(2)There was no statistical difference between the two groups in gender,age,cancer type,5-fluorouracil drug use,KPS score,ulcer number,ulcer diameter,etc.before treatment(p>0.05).(3)After treatment,there were 9 cases of grade 0,8 cases of grade I,5 cases of grade II,8 cases of grade III,and 0 cases of grade IV in the control group,and 17 cases of grade 0,7 cases of grade I,3 cases of grade II,3 cases of grade III,and 0 cases of grade IV in the treatment group,p=0.022 < 0.05.After treatment,the grade of oral mucositis in the treatment group decreased more significantly than that in the control group.(4)After treatment,there were 17 cases with 0-3 points,5 cases with4-6 points,and 8 cases with 7-10 points in the control group.There were 24 cases with 0-3 points,3 cases with 4-6 points,and 3cases with 7-10 points in the treatment group,p=0.048 < 0.05,indicating that the degree of pain in the treatment group was lower than that in the control group after treatment.(5)After treatment,the TCM syndrome score of the control group was 9.50 ± 1.59,and the TCM syndrome score of the treatment group was 8.17 ± 1.23,p=0.001<0.05,indicating that the TCM syndrome score of the treatment group was significantly lower than that of the control group.(6)The ulcer diameter was 0.69 ± 0.58 in the control group and 0.38 ± 0.50 cm in the treatment group,p=0.03 < 0.05,indicating that the treatment group could significantly reduce the ulcer diameter compared with the control group.(7)The number of ulcers was 1.33 ± 1.21 in the control group and 0.90 ± 1.52 in the treatment group,p=0.038<0.05,indicating that the number of oral ulcers in the treatment group was significantly lower than that in the control group.(8)KPS score,3 cases with 60-69 points in the control group,13 cases with 70-79 points,9 cases with 80-89 points,and 5 cases with 90-100 points;There were 4 cases in the treatment group with 60-69 points,13 cases with 70-79 points,10 cases with 80-89 points,and 3 cases with 90-100 points.p=0.604>0.05,indicating that there was no significant difference in KPS scores between the two groups after treatment.(9)After treatment,the local efficacy of ulcers was evaluated,and 9 cases were cured,13 cases were effective,and 8 cases were ineffective in the control group;There were 17 cases cured,10 cases with apparent effect,and 3 cases ineffective in the treatment group,p=0.025<0.05,indicating that the treatment group had a good curative effect.Conclusion: Jiawei Daochi Powder and Kangfuxin Liquid can significantly improve the oral mucositis caused by chemotherapy drugs,in terms of ulcer diameter,ulcer number,oral mucositis grading,pain score and TCM syndrome score.Therefore,the clinical promotion and application of modified Daochi powder will greatly relieve clinical symptoms,improve the quality of life of patients,and even improve the compliance of patients.It is an effective supplement for modern medicine to treat chemotherapy-related oral mucositis,and is worthy of further clinical promotion and application. |
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