Meta-Analysis Of Clinical Efficacy And Safety Of Qianzheng Powder In The Treatment Of Facial Neuritis

Objective:Objective: This study aims to conduct a meta-analysis of the efficacy and safety of Qianzheng Powder in the treatment of facial neuritis.To provide further reliable basis for the clinical decision of Qianzheng Powder in the treatment of facial neuritis.Methods: The computer was used to search the clinical randomized controlled trial(RCT)of the treatment of facial neuritis patients with Qianzheng powder published on December 1,2022 from the establishment of the database at home and abroad.After screening the relevant literature,the results of all the included literature were analyzed and integrated(using Rev Man5.3 software).Results: Finally,22 studies were included,of which 7 were treated with Qianzheng powder alone,and 15 were treated with Qianzheng powder combined with conventional western medicine,with a total of 2116 cases.Meta analysis: A total of 21 papers reported clinical efficacy,and subgroup analysis was carried out according to different treatment methods.The results showed that the effectiveness of Qianzheng powder in improving facial neuritis was better than that of the control group,and the difference was statistically significant(single use of Qianzheng powder: RR=1.30,95% CI[1.20,1.41],P=0.00001;Qianzheng powder combined with conventional western medicine: RR=1.22,95% CI [1.17,1.28],P=0.0001);A total of 18 papers reported the cure rate,and subgroup analysis was carried out according to different treatment methods.The results showed that Qianzheng Powder was superior to the control group in improving the cure rate of facial neuritis,and the difference was statistically significant(Qianzheng Powder alone:RR=1.73,95% CI [1.40,2.13],P=0.0001;Qianzheng Powder combined with conventional western medicine: RR=1.73,95% CI [1.51,1.99],P=0.0001);A total of 2 papers reported the Toronto facial nerve function score,and the results showed that after treatment,the observation group was better than the control group in improving the Toronto facial nerve function score of patients with facial neuritis(MD=8.12,95% CI [7.55,8.69],P=0.0001<0.05);A total of 2 papers reported the score of facial nerve paralysis degree.The results showed that the score of facial nerve paralysis degree in the observation group was better than that in the control group after treatment(MD=11.37,95% CI[4.97,17.78],P=0.0005<0.05);Five studies specifically reported adverse events,and the results showed that there was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(RR=0.36,95% CI [0.13,1.03],P=0.06).Conclusions: 1.Compared with the control group,Qianzheng Powder has significant advantages in improving the clinical efficacy and cure rate,improving the patient’s Toronto facial nerve function score and facial nerve paralysis score,and has good safety.2.There are still some limitations in this study.At present,the quality of the literature on the treatment of facial neuritis with Qianzheng Powder is low,which to some extent affects the reliability of the research results.In the future,more large-sample,multi-center,double-blind,randomized controlled clinical trials should be carried out to verify its efficacy and safety.