| Objective: To investigate the clinical effect of Zhuangyi lotus needle cupping and removing blood stasis combined with Zhuangyao internal administration on Yin syndrome of knee osteoarthritis(Zhuangyi Luoki).Methods: A total of 60 patients with KOA were selected from the orthopedic Clinic of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2020 to December 2022.Random number table method was used to divide the experimental group and the control group,30 cases in each group.The control group was treated with oral eroxib tablets,and the experimental group was treated with Zhuang medicine lotus needle cupping and removing blood stasis combined with Zhuang medicine.Lotus needle cupping and removing stasis therapy 3 times a week,Zhuangyao taken internally 1 dose a day,the course of treatment for 3 weeks.VAS scores and JKOM scores of the two groups were compared and analyzed before treatment,1 week after treatment and 3 weeks after treatment,to evaluate the clinical efficacy and safety of Zhuangyi Lianhua needle cupping and removing blood stasis combined with Zhuangyao internal administration in the treatment of Yin syndrome of early and middle stage knee osteoarthritis(Zhuangyi Luoki)..Results: Follow-up was completed in all patients and no shedding occurred.There was no statistically significant difference in the general baseline data indexes(gender,age,course of disease,location of disease,and body mass index)between the two groups(P > 0.05),and there was no statistically significant difference in VAS score,JKOM score,and all parts of JKOM between the two groups before treatment(P > 0.05),indicating comparability.Comparison and analysis between the two groups and within the two groups after treatment were as follows: 1.VAS score:(1)Comparison within the group:Statistical analysis showed that Z =-0.104,P = 0.917(P > 0.05)was comparable between the two groups before treatment.After 1 week of treatment,Z =-1.005,P = 0.315(P > 0.05)between the two groups,and after 3 weeks of treatment,Z=-4.799,P<0.001.(P > 0.05).The results indicated that the median VAS score of both groups decreased after 1 week of treatment,but the difference between the two groups was not significant,and the two groups had similar efficacy.After three weeks of treatment,there was a significant difference between the two groups,and the median VAS score of the experimental group decreased more,indicating that the therapeutic effect of the experimental group was better than that of the control group.(2)Inter-group comparison: Wilcoxon signed rank sum test was used to compare the two groups before and after treatment.The experimental group was compared before and after treatment with Z =-4.887,P < 0.001;after 1 week,Z =-4.861,P < 0.001;after 3 weeks,Z =--4.876,P < 0.001.In the control group,Z =-4.853,P < 0.001 before treatment,Z =-4.852,P < 0.001 after 1 week,and Z =--4.877,P < 0.001 after 3 weeks.The differences were statistically significant,indicating that with the increase of treatment course,the two groups were significantly improved after treatment.2.JKOM scores(1)Intra-group comparison: Independent sample t test was used.Before treatment,there was no statistical significance in pain,daily,social,and joint(P > 0.05),and the differences were comparable.The comparison of pain items between the two groups was: 1 week after treatment t = 1.461,P =0.149 >0.05,3 weeks after treatment t =-7.402,P<0.001,1 week after daily life treatment t =-1.439,P = 0.155>0.05,3 weeks after treatment t =-5.624,P<0.001,After 1 week of treatment for social activities,t =-0.882,P=0.381>0.05;after 3 weeks,t =-4.438,P<0.001;after 1 week of treatment for joint health,t =-0.564,P= 0.575>0.05;after 3 weeks,t =-2.855,P=0.006<0.05,indicating that the difference was significant.The curative effect of the two groups was similar,and there was a significant difference between the two groups at the third week of treatment,and the curative effect of the treatment group was significantly better than that of the control group.(2)Comparison between groups: The paired sample t test was used,and the internal pain,daily life,daily life and joint in both groups were better after treatment than before treatment(P < 0.001).The results indicated that with the increase of the course of treatment,both groups were significantly improved after treatment.(1)Intragroup comparison: The total score of jkom was compared between groups before and after treatment,and the rank sum test of two independent samples was used in both groups.The results showed that Z = 0,P = 1(P > 0.05)was comparable between the two groups before treatment.After 1 week of treatment,Z =-2.265,P = 0.024(P > 0.05)between the two groups,and after 3 weeks of treatment,Z =-5.296,P<0.001.The results indicated that after 1 week of treatment,the median of total JKOM score decreased in both groups,but the difference between the two groups was not significant,and the two groups had similar efficacy.After three weeks of treatment,there was a significant difference between the two groups,and the median total JKOM score of the experimental group decreased more,indicating that the therapeutic effect of the experimental group was better than the control group after three weeks of treatment.(2)Inter-group comparison: Wilcoxon signed rank sum test was used to compare the two groups before and after treatment.In the experimental group,Z =-4.808,P < 0.001,1 week after treatment,Z =-4.792,P < 0.001,and 3weeks after treatment,Z =-4.802,P < 0.001.In the control group,Z =-4.808,P < 0.001 before treatment,Z =-4.791,P < 0.001 after 1 week,and Z =-4.791,P < 0.001 after 3 weeks.The differences were statistically significant,indicating that with the increase of treatment course,the two groups were significantly improved after treatment.4.Comparison of the total efficacy of the disease: the overall effective rate of the experimental group was 96.67%,the overall effective rate of the control group was 80%.Chi-square test was used in the two groups,P = 0.04,the difference was statistically significant,indicating that the overall efficacy of the experimental group was better than that of the control group.During the study period,no adverse reactions or serious complications occurred in both groups.Conclusion: 1.In the treatment of Yin syndrome of knee osteoarthritis in the early and middle stages(Luo Jihe,Zhuang doctor),lotus needle cupping and removing blood stasis therapy combined with Zhuang medicine for internal administration can alleviate knee pain and knee stiffness to a certain extent,improve knee mobility function,and improve the quality of life of patients.2.Zhuangyi lotus needle cupping and removing blood stasis therapy combined with Zhuangyao internal administration in the treatment of Yin syndrome of early and middle stage knee osteoarthritis(Zhuangyi Luoki)can significantly reduce the VAS and JKOM scores of patients with accurate efficacy.3.In the course of this experiment,no adverse reactions were observed in all enrolled patients,indicating that the lotus needle cupping and removing blood stasis therapy of Zhuang medicine is safe and worthy of further promotion. |
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