| Objective: The purpose of this study is to observe the clinical efficacy and influence on anxiety and depression,and explore the mechanism of action through the clinical study on the treatment of polycystic ovary syndrome with kidney deficiency and liver depression syndrome by Bushen-Shugan prescription combined with Daying-35,so as to provide a powerful scientific basis and treatment ideas for clinical treatment.Methods: A total of 72 patients who met the inclusion criteria for polycystic ovary syndrome syndrome of kidney deficiency and liver depression were selected from January 2021 to August 2022 in the gynecological clinic of Ren’ai Branch,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine.According to random number table method,they were divided into treatment group(n=36 cases,1 case shedding)and control group(n=36 cases,1 case shedding).The control group was treated with Danyin-35,and the treatment group was additionally treated with Bushen Shugan prescription for 3 consecutive menstrual cycles.By observing the changes of menstruation,TCM syndrome score,body mass index(BMI),waist-to-hip ratio(WHR),sex hormone level and glucose metabolism index,anxiety score(SAS),depression score(SDS)and sleep quality index(PSQI)before and after treatment,the difference of efficacy between the two groups was compared.Follow-up was continued for 3 months after drug withdrawal to observe the patient’s menstrual cycle and menstrual volume.The final collected clinical data were sorted out and recorded into excel,and the results were statistically analyzed using SPSS25.0.Results:(1)Comparison of baseline data before treatment: there were no statistical differences in age,course of disease,menstrual cycle,menstrual volume,TCM syndrome score,BMI,WHR,hormone level,glucose metabolism level,anxiety and depression score and PSQI between the two groups before treatment(P > 0.05),indicating good balance and comparability.(2)SAS score was positively correlated with BMI,serum PRL and T(P < 0.05);SDS score was positively correlated with menstrual score,sleep quality and serum T level(P < 0.05).(3)Comparison of BMI and WHR: After treatment,BMI and WHR in treatment group were decreased compared with before treatment(P < 0.05);BMI and WHR in control group were not significantly improved(P > 0.05).The improvement of BMI in the treatment group was better than that in the control group(P < 0.05).There was no significant difference between the two groups after WHR treatment(P > 0.05).(4)Comparison of menstruation:(1)After treatment,the menstrual cycle and menstrual volume of the two groups were improved(P < 0.05),but there was no significant difference between the two groups after treatment(P > 0.05);(2)After 3 months of follow-up,the menstrual cycle and menstrual volume of both groups were improved compared with that before treatment(P < 0.05),and the curative effect of the treatment group was better than that of the control group(P < 0.05).(5)Comparison of TCM syndrome scores:(1)Comparison of total TCM syndrome scores: After treatment,the total TCM syndrome scores of the two groups decreased compared with that before treatment,P < 0.05,and the curative effect of the treatment group was better than that of the control group(P < 0.05).(2)Comparison of single scores of TCM syndrome: before and after treatment,there were significant differences between the two groups in the single TCM syndrome of waist and knee tenderness,mental depression,irritability and irritability,chest and hypochondriac swelling pain,upset,insomnia,dizziness and tinnitus(P < 0.05);The symptoms of dry mouth and bitter mouth in the treatment group were improved after treatment(P < 0.05),but there was no significant difference in the control group before and after treatment(P > 0.05).Compared between the two groups,the improvement degree of the treatment group was better than that of the control group on the symptoms of waist and knee soreness,depression,irritability,dry mouth and bitter mouth(P < 0.05),but there was no significant difference in the treatment effect of the two groups on thorax and hypochondriac pain,upset insomnia,dizziness and tinnitus(P > 0.05).(6)Comparison of serological indexes:(1)After treatment,serum LH,T,LH/FSH and AMH values of the two groups were decreased compared with before treatment(P < 0.05),FSH and E2 of the two groups were not significantly different before and after treatment(P > 0.05),PRL of the treatment group was decreased after treatment(P < 0.05),while RPL of the control group was not significantly different(P > 0.05).There were no significant differences in the values of FSH,E2 and T between the two groups(P > 0.05),but there were statistically significant differences in serum LH,PRL,LH/FSH and AMH between the two groups(P < 0.05),and the treatment group was better than the control group.(2)There were statistically significant differences in FINS and HOMA-IR before and after treatment between the two groups(P < 0.05),both of which were lower than before treatment;FPG in the treatment group was lower than that before treatment(P < 0.05),but there was no significant difference in FPG in the control group(P > 0.05).There were no significant differences in FPG,FINS and HOMA-IR values between the two groups(P > 0.05).(7)Comparison of SAS,SDS and PSQI scale scores:(1)SAS score and SDS score of 2 groups were significantly decreased after treatment compared with before treatment(P < 0.05).The SAS score of the treatment group was significantly lower than that of the control group(P < 0.05).There was no significant difference in SDS score between 2 groups after treatment(P > 0.05).(2)PSQI in the treatment group was significantly improved after treatment compared with that before treatment(P < 0.05),while there was no significant difference in the control group before and after treatment(P > 0.05);There was statistical significance in sleep quality between the two groups(P < 0.05).(8)Comparison of curative effect:(1)Comparison of curative effect of TCM syndroms: After treatment,the total effective rate of TCM syndroms was 97.14%in the treatment group and 77.14% in the control group.After rank sum test,P< 0.05,the difference was statistically significant,indicating that the curative effect of the treatment group was significantly superior to the control group in terms of the curative effect of TCM syndroms.(2)Comparison of comprehensive efficacy: After treatment,the total effective rate of the treatment group was 85.71%,and the total effective rate of the control group was 65.71%.There were significant differences between the two groups(P <0.05),and the comprehensive efficacy of the treatment group was significantly better than the control group.Conclusion(s): 1.The clinical comprehensive effect of Bushen Shugan prescription combined with Dain-35 in the treatment of patients with polycystic ovary syndrome with kidney deficiency and liver depression is better than that of Dain-35 alone,and the TCM syndrome has significant effect.2.Bushenshugan prescription combined with Daying-35 can better improve the clinical symptoms of patients with PCOS syndrome of kidney deficiency and liver depression,regulate the basic endocrine level,effectively improve patients’ menstrual cycle and menstrual period,maintain the therapeutic effect for a longer time,and improve patients’ anxiety,depression and sleep quality. |
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