Analysis Of The Efficacy Of Loaded Antibiotic Calcium Sulfate In The Treatment Of Open Fracture Wound Infection Of The Foot

ObjectiveThis topic discusses the analysis of the efficacy of the treatment of open fracture wound infection of the foot with load antibiotic calcium sulfate.MethodsThis study is a prospective randomized observational study.Patients with unilateral open foot fractures of Gustilo type IIIA with trauma infection in the nonweight-bearing area and trauma area larger than 5*5 cm were admitted to the Department of Foot and Ankle Surgery of the hospital from October 2020 to September2022.Patients were given a complete debridement of the infected lesion in phase I.The fracture was fixed with either a Clinique pin or an external fixation brace,as appropriate,and the wound was continuously flushed and drained with vacuum sealing drainage(VSD)and removed after 4 to 5 days.Infected necrotic tissue was removed again or repeatedly,depending on the condition of the wound,and bacterial sensitivity cultures were obtained every 3 days during this treatment.For the 30 patients with S.aureus infection,the patients were divided into control and observation groups(n=15)according to the random number table method,depending on the treatment method.The control group was given lesion debridement again,along with adequate local irrigation followed by continuous irrigation and drainage of the trauma with VSD,and then given the antimicrobial drug selected by the drug sensitivity test results for systemic control treatment.In the observation group,patients were treated with vancomycin calcium sulfate granules implanted on top of the above treatment.The patients in both groups were monitored for infection indexes once before surgery and the VSD treatment was changed every 4 to 5 days after surgery,and bacterial drug sensitivity culture was taken every 3 days during the treatment period and infection indexes were monitored every 7days.The levels of CRP(C-reactive protein),PCT(calcitoninogen),ESR(sedimentation),and WBC were compared between the two groups before and at weeks1,2,and 3 after surgery,and the bacterial clearance time and wound healing time were also compared.ResultsThe differences in age,gender and left and right sides of the affected limbs between the two groups were not statistically significant.2.The pathogen clearance time between the two groups was 22.80±4.22 d in the control group and 17.13±3.15 d in the observation group(t=4.157,p=0.000).The time to wound healing was 58.13±8.86 d in the control group and 49.86±6.95 d in the observation group(t=2.841,P=0.008,the difference between the two groups was statistically significant(t=2.841,P=0.008).4,The levels of CRP(C-reactive protein),PCT(calcitoninogen),ESR(sedimentation),and WBC in the two groups decreased in the first,second,and third postoperative weeks,but the observed indexes decreased more significantly in the observation group in the second and third postoperative weeks,which can indicate that the observation group was better than the control group in terms of infection control.ConclusionLoaded antibiotic calcium sulfate in the treatment of open fracture wound infections of the foot improves infection control,as well as bacterial clearance time and wound healing time.