Analysis Of Related Factors Of Cirrhotic Portal Hypertensive Gastropathy

Objective:To retrospectively analyze the related serological indexes,imaging indexes and gastroscopy results of patients with cirrhosis during hospitalization,and to explore the independent risk factors of portal hypertensive gastropathy in cirrhosis.Early identification and monitoring of related risk factors and timely treatment are beneficial to further improve the clinical prognosis of patients.Methods:Patients with cirrhosis in the hospital between November 2020 and October 2022 in the Department of Gastroenterology,Yantai Hospital were collected through the case browsing system,and 142 cases were finally included according to the inclusion and exclusion criteria,whether the information was complete.The general clinical data of the patients were recorded,and the study subjects were divided into PHG group and no PHG group according to the results of gastroscopy report,and the endoscopic diagnostic criteria of PHG(Portal hypertensive gastropathy,PHG)were based on Mc Cormack’s classification,and the general data of the combined PHG group and the no PHG group such as gender,age,etiology and The data of laboratory indexes such as VEGF,PGI,PGII,AST,liver and spleen hardness,spleen length,portal vein width and other imaging indexes were imported into SPSS,and then the corresponding statistical analysis was performed according to the exploration results.ROC curves were drawn for the relevant indicators to predict the occurrence of PHG.Results:1.Comparison of general information between the cirrhosis combined PHG group and the non-combined PHG group: there was no statistical difference between the two groups in terms of gender,age,and etiology(P > 0.05).2.Results of univariate analysis in both groups:(1)The difference between different degrees of esophageal varices compared with the presence or absence of combined PHG was statistically significant(χ~2=12.464,P<0.05).Further subgroup analysis yielded statistically significant differences in the composition ratios of mild EV and moderate/severe EV with and without combined PHG.There was no statistical difference between the two groups in the comparison of different liver function grades,different ascites grades,and different subtypes of H.pylori infection.(2)Hb,RBC,VEGF,AST,ALT,and SF were statistically different in the comparison between the two groups with and without PHG(P < 0.05).ALB,SCR,NO,PGI,PGII,G-17,PT,TBIL,and PLT were not statistically different in the comparison between the two groups.(3)Spleen length and spleen thickness were statistically different in the two groups,(Z=-3.615,P=0.001 and Z=-2.507,P=0.012).Liver stiffness,spleen stiffness,portal vein width and the presence of portal vein thrombosis were not statistically significant in the two groups.3.Further comparison of PHG of different severity: Hb,spleen length,spleen thickness,AST,and EV were statistically different in the three groups with P < 0.05.4.Results of multifactorial analysis in both groups: VEGF and spleen length were independent risk factors for the development of portal hypertension in liver cirrhosis.Conclusion:1.According to univariate analysis,there are statistical differences in EV degree,Hb,RBC,VEGF,AST,ALT,SF,spleen length and spleen thickness between the two groups.2.Multivariate analysis obtained that VEGF and spleen length were independent dangerous factors for cirrhosis portal hypertension3.The values of VEGF and spleen length in patients with PHG due to liver cirrhosis were significantly higher than those in patients without PHG due to liver cirrhosis.The combination of VEGF and spleen length can predict PHG better.