Correlation Study Between Podoplanin And Venous Thromboembolism In Patients With Ovarian Cancer

Object:Ovarian cancer patients have a higher risk of venous thromboembolism(VTE),which is one of the reasons that affect cancer treatment and increase medical costs.The mechanism of venous thrombosis in ovarian cancer patients is still unclear.podoplanin is a transmembrane glycoprotein which can promote thrombosis.We sought to evaluate the relationship between cancer tissue podoplanin expression and VTE development,microvascular density(MVD),and prothrombotic status in patients with ovarian cancer.Methods:We performed a case-control study of ovarian cancer patients with and without VTE.A total of 168 patients diagnosed with ovarian cancer at Xiangya Hospital of Central South University between December 1,2016 and May 31,2021 were included.The clinical data of the patients were collected.Immunohistochemical(IHC)was used to evaluate the expression of podoplanin and MVD value in cancer tissues.A COX proportional hazards regression model was used to investigate the association of podoplanin and other risk factors with the risk of VTE.Results:Of the 168 ovarian cancer patients,76(45.24%)had high expression of podoplanin in the cancer tissues.Among the 60 patients with VTE,38(63.33%)had high expression of podoplanin in the cancer tissues.In addition,38(35.18%)of 108 patients without VTE had high expression of podoplanin in cancer tissues.The high expression of podoplanin in cancer tissue was associated with the occurrence of VTE in patients(p=0.002).And podoplanin expression was positively correlated with MVD(p=0.006).The high expression of podoplanin may be related to the hypercoagulable state of patients.After adjusting for the risk factors of age,histology,the risk of VTE in patients with high expression of podoplanin still increased 2.64 times(HR=2.64,95 CI 1.36-3.84).Conclusions:High expression of podoplanin in ovarian cancer tissue can increase the risk of venous thromboembolism in patients.Moreover,MVD was high in carcinoma tissues with high podoplanin expression,which may provide new insights into the mechanistic study of VTE formation in ovarian cancer patients.