A Study Of Director Wang Sheng’s In Treating Pulmonary Nodules With Syndrome Differentiation Based On Data Mining

Objective: To analyze the cases of pulmonary nodules in director Wang Sheng’s outpatient clinic by data mining technology,and summarize the clinical thinking of director Wang Sheng’s treatment of pulmonary nodules based on syndrome differentiation.Methods: From December 2020 to October 2022,the outpatient Department of Respiratory Medicine of Anhui Hospital of Traditional Chinese Medicine chose 123 patients with pulmonary nodules.The data from these patients was then entered into the Information Center of Anhui Hospital of Traditional Chinese medicine’s Clinical Medical Record Collection System V3.1 and Clinical Medical Record Data Processing System V3.1 to form a database.Frequency,association,cluster analysis of patients with general conditions,combined disease,syndrome,TCM symptoms,tongue coating,pulse,traditional Chinese medicine,and core prescription were all analyzed.Results:An average age of 53.81 years was the average of 123 patients,47 male and 76 female,who were part of the study.The top ten TCM symptoms that appeared in 123 visits,ranked from high to low,were fatigue,cough,chills,irritability,insomnia,chest tightness,and dry mouth,all of which were repeated more than four times.Anticipation,chest ache,stomach distress,like signing;The frequency of 14 tongue coating and pulse condition varieties varies from high to low,thin white fur(112 times),light red tongue(108 times),thin red tongue(93 times),teeth marks on tongue(20 times),red tongue(13 times),thin and smooth pulse(11 times),thin and smooth pulse(7 times),thin yellow fur(6 times),thin and thin pulse string(6 times),smooth pulse string(4 times),thin and white fur(3 times),little fur(2 times),light and dark red tongue(2 times),slippery pulse(2 times);The top five comorbidities in terms of frequency were Thyroid Nodule,Breast Nodules,Chronic Gastritis,Type 2 Diabetes and Hypertension;Frequencies of 4 types of syndrome,ranging from high to low,are as follows:combination of phlegm and blood stasis,stagnation of liver-qi,deficiency of both Qi and Yin,and deficiency of both lung and spleen.127 drugs were divided into 18 kinds,with total use of 2,147.Of these,the top 20 flavours in terms of frequency were Ground Beetle,Hedyotis diffusa,Fructus aurantii,Chinese angelica,Radix Glycyrrhizae Preparate,Fritillaria thunbergii,Lily,Astragalus Membranaceus,Turtle shell,Scutellaria,Codonopsis pilosula,Bupleurum root,Atractylodes macrocephala,Coix seed,Iphigenia,Radix adenophorae,Gleditsia spinifera,Oyster,Turmeric Root-tuber,and Radix paeoniae alba.Among them,tonic for deficiency drugs(Qi and Yin-tonifying drugs are common),heat-clearing drugs(heat-clearing and antidote drugs are common),phlegm-resolving drugs(include phlegm-warming drugs and heat-clearing and phlegm-resolving drugs),drugs for promoting blood circulation and removing blood stasis,qi-regulating drugs;the flavor is typically cold,slightly cold,warm,flat,sweet,bitter,bitter,salty.The main tropism channels are the liver,lung,spleen,heart,and stomach.Drug combinations: In order of confidence from high to low,drug pairs in the top 10 were Radix adenophorae-Lily,Agrimoniae Herba-Lily,Agrimoniae Herba-Ground Beetle,Radix paeoniae alba-Radix Glycyrrhizae Preparate,Coix seed-Ground Beetle,Codonopsis pilosula-Radix Glycyrrhizae Preparate,Dendrobium-Ground Beetle,Gleditsia spinifera-Ground Beetle,Atractylodes macrocephala-Ground Beetle,Radix adenophorae-Ground Beetle;The three drugs and the four drugs were mainly: supplementing qi,nourishing Yin,dispersing liver-qi,dispersing qi,and invigorating spleen and lung;Four groups of cluster prescriptions were obtained: Group1: Bupleurum root,Semen Litchi,Turmeric Root-tuber,Radix paeoniae alba,oyster;Group 2: Rhizoma Pinelliae Praeparatum,Dried citrus peel,Indian buead,atractylodes macrocephala,codonopsis pilosula,baked licorice,leech,oyster;Group 3: Radix adenophorae,Agrimoniae Herba,Lily,Dendrobium,Coix seed,Scutellaria,Ground Beetle,Chinese angelica,Astragalus Membranaceus;Group 4:Hedyotis diffusa,Iphigenia,Fructus aurantii,Fritillaria thunbergi,turtle shell,Polygonatum kingianum,Ranunculus ternatus Thunb,Euphorbia helioscopia,Gleditsia spinifera.In the end,the core prescription was: Ground Beetle,Chinese angelica,Hedyotis diffusa,Scutellaria,Codonopsis pilosula,Coix seed,Iphigenia,Fritillaria thunbergii,Fructus aurantii,Dendrobium,Turtle shell,Ranunculus ternatus Thunb,Gleditsia spinifera,Euphorbia helioscopia,Radix Glycyrrhizae Preparate.Conclusion: According to Professor Wang’s analysis,the etiology and pathogenesis of pulmonary nodules are the common causes of deficiency of vital energy,attacking of exogenous evils,Pathogenesis of pulmonary nodules is rooted in emotional trauma and an unhealthy dietary pattern,which can lead to stagnation of Phlegm and Qi,blood stagnation and toxins.Pathological elements such as qi stagnation,blood stagnation,cold pathogen,toxin knot,and phlegm coagulation were all present.Four distinct types of syndrome exist: a combination of phlegm and blood stagnation,stagnation of liver-qi,deficiency of both Qi and Yin,and a deficiency of both lung and spleen.The main therapeutic methods are dispersing phlegm,dispersing liver and promoting qi,supplementing qi and nourishing Yin,strengthening spleen and benefiting lung.Professor Wang usually used heat-clearing and detoxification drugs and insect drugs,which embodied Professor Wang’s clinical thinking of treating pulmonary nodules by resolving phlegm,dispersing knot,promoting blood circulation and removing blood stasis.