Changes Of Retinal And Choroidal Thickness In Macular Area In Patients With Hypertension And Analysis Of Factors Related To Choroid Thickness

Objective:Retinal and choroidal thickness was measured by EDI mode in SD-OCT to observe the changes of retinal and choroidal thickness in the macular area in patients with hypertension in this study,and the related factors of the subfoveal choroidal thickness were analyzed.To investigate the risk factors of hypertensive retinopathy and provide theoretical basis for the clinical study of hypertensive retinopathy.Methods:This cross-sectional study recruited a total of 105 eyes of 62 patients with hypertension at the Ophthalmology Department of the Affiliated Hospital of Chengde Medical University between December 2020 and December 2022 in hypertensive group,including 53 eyes of 30 males and 52 eyes of 32 females.Another 56 eyes of 28 healthy subjects without hypertension were collected in control group,including 28 eyes of 14 males and 28 eyes of 14 females.With the fovea of macula as the center,the EDI pattern with spectral domain optical coherence tomography(SD-OCT)was used to measure the mean retinal thickness and choroidal thickness in the foveal region with a diameter of 1 mm(foveal region),1 – 3 mm(inner macula regions: superior,inferior,temporal,and nasal),and 3 – 6 mm(outer macula regions: superior,inferior,temporal,and nasal),and The differences of mean retinal thickness and choroidal thickness between the two groups were compared,and the correlation between subfoveal choroidal thickness and the basic data of hypertensive patients was analyzed.Results:1.There was no significant difference in gender,age,spherical equivalent refraction,intraocular pressure and axial length between the two groups(P > 0.05).2.Except for the fovea,the retinal thickness in the hypertensive group was statistically significant compared with the control group(P < 0.05);the retinal thickness in the macular area in the hypertensive group became thinner compared with the control group.3.There were significant differences in choroidal thickness between the hypertensive group and the control group(P < 0.05);the choroidal thickness in the macular area in the hypertensive group became thinner compared with the control group.4.Univariate linear regression analysis showed that there was a negative correlation between the subfoveal choroidal thickness and gender,age,systolic blood pressure and diastolic blood pressure in patients with hypertension;then stepwise regression analysis revealed that there was still a negative correlation between the subfoveal choroidal thickness and age and systolic blood pressure(P < 0.05).Conclusions:1.The mean retinal and choroidal thickness in the macular area became thinner in patients with hypertension than in healthy subjects.2.The correlation between the duration of hypertension and subfoveal choroidal thickness is not significant.3.Age and systolic blood pressure are still important factors affecting subfoveal choroidal thickness in hypertensive patients.