Clinical Observation Of Xionggui Zhitong Decoction Combined With Carbamazepine In The Treatment Of Primary Trigeminal Neuralgia

Obj ective:In this study,Xionggui Zhitong Decoction combined with carbamazepine was used to treat primary trigeminal neuralgia.By observing the improvement of pain VAS score,Pittsburgh Sleep Quality Index(PSQI),serum endorphin content and clinical symptoms before and after treatment in the two groups,the clinical efficacy,scale score improvement and β-endorphin level in the two groups were compared to explore the mechanism and efficacy advantages of Xionggui Zhitong Decoction combined with carbamazepine in the treatment of primary trigeminal neuralgia.Method:Sixty patients with primary trigeminal neuralgia who met the inclusion criteria were divided into control group and experimental group by random single-blind method.The control group was treated with carbamazepine routine treatment;the experimental group was treated with Xionggui Zhitong decoction on the basis of the control group.The pain VAS score,Pittsburgh sleep quality index,serum βendorphin content and total effective rate of clinical symptom improvement were observed and compared between the two groups before and after treatment.SPSS 26.0 software was used for data processing and statistical analysis.Results:1.After treatment,the improvement of pain VAS score,the incidence of adverse reactions and the improvement of Pittsburgh sleep quality index in the experimental group were higher than those in the control group(P<0.05).2.After treatment,according to the change of serum β-endorphin content,the content of β-endorphin in the experimental group was better than that in the control group(P<0.05).3.After treatment,the total effective rate of the treatment group was 92.9%,and that of the control group was 82.1%,which was statistically different(P<0.05).Conclusion:1.Xionggui Zhitong decoction combined with carbamazepine can improve the condition of patients with primary trigeminal neuralgia,increase the content of β-endorphin in patients,and reduce the clinical symptoms of patients.2.Primary trigeminal neuralgia can be treated with Xionggui Zhitong Decoction combined with carbamazepine,and the clinical efficacy is better than that of carbamazepine alone,with low adverse reactions.