Effect Of Polyethylene Glycol Electrolyte Solution Added Mizone On The Compliance And Tolerance Of Patients With Bowel Preparation

Background:The unpleasant taste of polyethylene glycol(PEG)was a hindrance to patients undergoing colonoscopy.The aim of this study was to determine whether the addition of a vitamin drink(Mizone)to a 4L polyethylene glycol regimen would be effective in improving solution palatability and reducing patient discomfort during bowel preparation.Methods:This was a prospective randomized controlled study.All enrolled patients were randomly assigned to 4L PEG+Mizone group(3.6 L PEG solution plus 0.4 L Mizone fluid)or 4L PEG group(4L PEG solution)for bowel preparation.Palatability was assessed on a Likert visual scale of 1 to 5.Boston scoring was used to evaluate the quality of bowel preparation.Serum electrolytes were measured before and after bowel preparation,and the results of colonoscopy were recorded.Adverse effects,the amount unconsumed solution and the willingness to repeat the same process were recorded by questionnaire.Results:A total of 132 patients,66 in the PEG+Mizone group and 66 in the PEG group who underwent colonoscopy were included in the study.The demographic characteristics of the patients were comparable between these two groups.The palatability score(mean ±SD)of PEG+Mizone group was higher that of control group(4.00±0.859 vs 2.95±0.999;P < 0.001).The incidence of nausea was lower in the PEG+Mizone group(9.1% vs 28.8%;P = 0.004)and other adverse effects were similar.The percentage of the prepared solution completely consumed was significantly better in the PEG+Mizone group(95.5% vs 78.8%,P = 0.004).Willingness to repeat the same process was higher in the PEG+Mizone group(83.3% vs 42.4%;P <0.001).Boston scale between two groups were not statistically significant(6.41±1.34 vs6.38±1.29,P = 0.895).Consumption of either preparation did not significantly affect electrolyte levels.Conclusion:Compared with the conventional 4L PEG bowel preparation,the use of vitamin drink(Mizone)as an adjuvant can improve the Palatability of patients,reduce the adverse effects.