Correlation Between FAR And Severity Of Coronary Artery Lesions In Patients With Premature Coronary Artery Disease

Objective: To discuss the role of FAR(Fibrinogen/Albumin ratio)in the development of premature coronary artery disease and the correlation between FAR and the severity of coronary artery disease in patients with premature coronary artery disease.Methods: Collect the relevant information of patients with chest pain,chest tightness and other symptoms who were admitted to the Department of Cardiology of our hospital from January 2018 to January 2020,male<55 years old,female<65 years old,and underwent coronary angiography(CAG)for the first time.According to the inclusion criteria and exclusion criteria,261 patients were selected and included in the retrospective analysis.After CAG,141 patients were diagnosed as premature coronary artery disease,and the other 120 patients were in the control group.Collect laboratory test indexes,angiographic data and baseline data of the two groups of patients during hospitalization and calculate FAR.According to the results of CAG examination,the corresponding position and number of coronary artery lesions were recorded and counted.The premature coronary artery disease group was divided into single,double,and multiple vessel lesion group;Gensini score(GS)was calculated,and patients were divided into low GS,medium GS,and high GS group according to the score results.Compare the differences of fibrinogen(Fib),albumin(ALB)and FAR levels among the groups,and explore the relationship between the three levels and the severity of coronary artery stenosis.Results:Compared with the control group,the levels of Fib and FAR in the premature coronary artery disease group increased,while the levels of ALB decreased,with a statistically significant difference(P<0.05).With the increase of the number of coronary artery lesions and the degree of stenosis,the level of Fib and FAR increased,while the level of ALB decreased;According to the Spearman correlation analysis we found that the levels of Fib and FAR were positively correlated with the number of coronary artery lesions and the degree of coronary stenosis in CHD,while ALB was the opposite.The comparison of the three showed that FAR had the strongest correlation.The ROC curve of the three predicted the severity of coronary artery disease in patients with premature coronary heart disease showed:Fib(AUC:0.800,SN:73.90%,SP:83.20%);ALB(AUC:0.925,SN:95.70%,SP:85.30%);FAR(AUC:0.991,SN:97.80%,SP:93.70%);It is suggested that FAR is more valuable than both in predicting the degree of coronary stenosis.Conclusions: Patients with premature coronary artery disease have a high level of FAR,which is helpful to evaluate the inflammatory load and the stability of coronary atherosclerotic plaque in patients with premature coronary artery disease.FAR was positively correlated with GS score and the number of coronary lesions,and was closely related to the severity of coronary lesions in patients with premature coronary artery disease.FAR is better than Fib and ALB in predicting the severity of coronary artery disease in patients with premature coronary artery disease.