Effect Of The Guidance Of Invigorating Qi And Activating Blood And Detoxification Method On Renal Function And Serum β2 Microglobulin In Patients With Acute Kidney Injury Of Sepsis (S-AKI) With Qi Deficiency And Blood Stasis

Objective:To observe the effect of Yiqihuazhuo Decoction,a traditional Chinese medicine prescription under the guidance of invigorating Qi and activating blood and detoxification method,on serum β2-MG and related clinical index-es in patients with acute kidney injury of sepsis(S-AKI)with qi deficiency and blood stasis.Method:Inpatients who met the diagnostic criteria for septic acute kidney injury were admitted from the Intensive Care Department of the First Affiliated Hospital of Heilongjiang University of Chinese traditional Medicine from September 2021 to January 2023.Sixty patients who met the inclusion criteria of this subject were divided into experimental group and control group according to random number table method.All patients in the two groups received conventional basic Western medicine treatment,specifically referring to the 2018 Chinese Guidelines for Emergency Treatment of Sepsis/Septic Shock,including anti-infection,blood purification,nutritional support and other symptomatic treatment.The treatment group was given oral traditional Chinese medicine(prescription components: Astragalus membran-aceus,codonopsis codonopsis,angelica sinensis,atractylodes atractylodes,ligusticum Chuanxiensis,poria cocos,Soodi,etc.).Before treatment,three days after treatment and seven days after treatment,the main outcome indicators serum β2-MG and secondary outcome indicators SOFA score,APACHEⅡ score,TCM syndrome score and other points,kidney function related indicators(BUN,Csy C,Scr)were collected and measured,the length of hospital stay was recorded,and the relevant data were analyzed.Result:1.After 3 days of treatment,serum β2-MG in both groups was improved compared with before treatment(p<0.05),but there was no significant difference between groups(p>0.05).After 7 days of treatment,serum β2-MG in both groups was improved,and the improvement in experimental group was more obvious(p<0.05).2.After 3 days of treatment,SOFA scores of both groups were improved compared with before treatment(p<0.05),but there was no significant difference between groups(p>0.05).After 7 days of treatment,SOFA scores of both groups were improved,and the improvement of experimental group was more obvious(p<0.05).3.After 3 days of treatment,APACHEⅡ scores in 2 groups were improved compared with before treatment(p<0.05),but there was no significant difference between groups(p>0.05).After 7 days of treatment,APACHEⅡ scores in 2 groups were improved,and the improvement in experimental group was more obvious(p<0.05).4.After 3 days of treatment,TCM syndrome scores of both groups were improved compared with those before treatment(p<0.05),and the improvement of the experimental group was statistically significant compared with the control group(p<0.05).After 7 days of treatment,TCM syndrome scores of both groups were improved,and the improvement of the experimental group was more obvious(p<0.05).5.After 3 days of treatment,BUN of the two groups were improved compared with before treatment(p<0.05),the improvement of the experim-ental group compared with the control group has statistical significance(p<0.05),after 7 days of treatment,BUN of the two groups of patients were improved,the improvement of the experimental group was more obvious(p<0.05).6.After 3 days of treatment,Csy C in both groups was improved compared with before treatment(p<0.05),but there was no significant difference between groups(p>0.05).After 7 days of treatment,Csy C in both groups was improved,and the improvement in experimental group was more obvious(p<0.05).7.After 3 days of treatment,the Scr of both groups was improved compared with that before treatment(p<0.05),and the improvement of the experimental group was statistically significant compared with the control group(p<0.05).After 7 days of treatment,the Scr of both groups was improved,and the improvement of the experimental group was more obvious(p<0.05).8.There was no significant difference in hospital stay between the two groups(P=0.858>0.05).9.In the course of treatment and observation in this study,there was one death,which was severe sepsis without underlying disease before.On the 6th day after enrollment,the patient died due to multiple organ failure.All the other 59 patients had drug-related adverse reactions.Conclusion:1.Yiqihuazhuo Decoction,a traditional Chinese medicine prescription under the guidance of invigorating Qi and activating blood and detoxification method can improve the serum β 2-MG level of S-AKI patients with Qi deficiency and blood stasis.2.Yiqihuazhuo Decoction,a traditional Chinese medicine prescription under the guidance of invigorating Qi and activating blood and detoxification method can improve SOFA score,APACHEⅡ score,TCM syndrome score and other scores with some extent.3.Yiqihuazhuo Decoction,a traditional Chinese medicine prescription under the guidance of invigorating Qi and activating blood and detoxification method can improve certain curative effect on BUN,Csy C,Scr and other indicators related to renal function.4.Yiqihuazhuo Decoction,a traditional Chinese medicine prescription under the guidance of invigorating Qi and activating blood and detoxification method is safe,with no adverse events and good safety.