The Study On The Correlation Between Blood Related Indexes During Pregnancy And Preeclampsia

Objective: By comparing the changes of peripheral blood biochemical indexes,coagulation indexes and blood routine indexes in pregnant and healthy pregnant women with preeclampsia,the correlation between each index and preeclampsia was discussed,which provided a strong basis for predicting and evaluating the severity of preeclampsia at the grassroots level in Xinjiang.Methods: According to the Guidelines for the Diagnosis and Treatment of Hypertensive Disorders in Pregnancy(2020),a total of 236 pregnant women in the preeclampsia group were included,including 102 cases of non-severe preeclampsia,134 cases of severe preeclampsia,and 200 healthy pregnant women were screened as the control group.The basic information and clinical data of different groups of pregnant women were analyzed for the differences between groups,and a multivariate logistic regression model was established to explore the correlation between each index and preeclampsia,and the ROC curve was drawn to indicate the predictive value of each index on preeclampsia through the area under the curve.Results:(1)Compared with the general data of the three groups of pregnant women,the differences in systolic blood pressure,diastolic blood pressure,preconceptional BMI,pregnancy weight,pregnancy time and birth times were statistically significant;There were significant differences in neonatal birth weight,gestational age at birth,and mode of delivery in pregnancy outcomes(P<0.05).(2)Among the biochemical indexes,renal function indexes BUN,Cr and UA were significantly higher than those in the preeclampsia group;TC,TG were significantly higher in the severe preeclampsia group than in the control group.Among the liver function indicators,TP and ALB were significantly lower than those in the control group with severe preeclampsia,and the differences were statistically significant(P<0.05).(3)APTT and PT were significantly lower in the coagulation index group than in the control group with severe preeclampsia,and the difference was statistically significant(P<0.05).(4)Among the blood routine indexes,WBC,RDW increased,PLT and PDW decreased significantly in the control group and the preeclampsia group(P<0.05).(5)Multivariate logistic regression analysis showed that BMI overweight and obesity before pregnancy,excessive weight gain during pregnancy,and nulliparous pregnancy were risk factors for non-severe preeclampsia and severe preeclampsia,and age above 35 years were risk factors for severe preeclampsia;After adjusting for confounding factors,elevated UA,TG,RDW,and decreased APTT were risk factors for both non-severe preeclampsia and severe preeclampsia,while elevated BUN,WBC,and decreased PLT were risk factors for severe preeclampsia.The AUC of blood indexes combined with maternal age,preconceptional BMI,weight gain during pregnancy and pre-eclampsia was 0.886(95%CI:0.856～0.916).Conclusion:(1)Advanced age,overweight and obesity before pregnancy,and excessive weight gain during pregnancy are risk factors for the occurrence of preeclampsia,especially severe preeclampsia.(2)Some blood indexes during pregnancy were correlated with the occurrence of preeclampsia,and blood indexes combined with maternal age,pre-pregnancy BMI,pregnancy weight gain and parity had high diagnostic value for preeclampsia.Therefore,the results of this study show that blood indicators may be related to the occurrence of preeclampsia,and strengthening the monitoring of blood indicators during pregnancy,grasping their dynamic change rules,early detection and early treatment may provide clinical guidance for the prevention and control of preeclampsia at the grassroots level in Xinjiang.