Clinical Efficacy Of Yiqiquanzhen Tang In The Treatment Of Chronic Kidney Disease Stage 3 (CKD3) On Patients With Spleen-Kidney Qi And Yin Deficiency Type And Its Effect On Serum,Urinary Type-Ⅳ Collagen Protein(Col-Ⅳ)

ObjectiveTo observe the clinical efficacy of Yiqiquanzhen Tang treatment on patients with Spleen-Kidney Qi and Yin Deficiency type Chronic Kidney Disease Stage 3(CKD3),and compare the changes of serum and urinary type Ⅳ collagen(Col-Ⅳ)before and after treatment,therefore,to explore the possible potential mechanism of Yiqiquanzhen Tang in the treatment of Spleen-Kidney Qi and Yin Deficiency type Chronic Kidney Disease Stage 3(CKD3)based on Yiqizhouliu theory.Methods60 patients with Spleen-Kidney Qi and Yin Deficiency type Chronic Kidney Disease Stage 3(CKD3)who met the inclusion criteria were enrolled and randomly divided into experimental group 30 cases and control group 30 cases,and actually 28 cases of experimental group and 28 cases of control group were completed.The control group were treated with conventional western medicine,and the experimental group were treated with the Yiqiquanzhen Tang on the basis of the treatment of the control group.The course of treatment was 12 weeks,and Clinical efficacy was evaluated every 12 weeks.To observe 24-hour urine protein(24h Upro),serum albumin(ALB),serum and urinary type-Ⅳ collagen(Col-Ⅳ),blood urea nitrogen(BUN),Serum Creatinine(Scr),Estimate Glomerular Flltration Rate(e GFR)and TCM syndrome integral changes were compared before and at the 12 th week of treatment.Results and data were analyzed by SPSS23.0.Results1.Before treatment,there was no significant difference in general data,clinical test indexes and total symptom scores between the control group and the experimental group(P>0.05),which was comparable.2.At the 6th and 12 th week of the treatment,the values of Scr,24 h Upro,BUN all decreased(P<0.05)and e GFR values increased in both groups(P<0.01),and the efficacy of the experimental group was better than that of the control group(P<0.05).Meanwhile,the values of ALB was higher than before in both of two groups(P<0.05).At the 12 th week of treatment,the difference between the two groups was statistically significant in 24 h Upro,BUN,Scr,e GFR(P<0.05),however,there was no significant difference in ALB between the two groups after treatment(P>0.05).3.After treatment,the levels of serum Col-Ⅳ and urinary Col-Ⅳ both decreased compared to that before treatment(P<0.01),and the experimental group was better than that of the control group.4.Serum and urinary Col-Ⅳ were negatively correlated with e GFR(P<0.01),while positively correlated with Scr,24 h Upro and BUN(P<0.01),and had no significant correlations with ALB(P>0.05).Besides,the correlation was statistically significant(P<0.05).5.After treatment,the TCM syndrome scores of both groups were lower than those in the pre-treatment ones(P<0.01),and the efficacy of the experimental group was better than that of the control group(P<0.01).The total effective rate of the efficacy of medical symptoms in the two groups was 85.71% in the experimental group and 65.71% in the control group,and the difference was statistically significant(P<0.05).6.In terms of the comprehensive clinical efficacy after treatment,the effective rate of the experimental group was 87.5%,and the effective rate of the control group was 63.64%,and the difference between the two groups was statistically significant(P<0.05),and the experimental group was better than the control group.Conclusions1.Yiqiquanzhen Tang combined with Western medicine has considerable efficacy on patients with Spleen-Kidney Qi and Yin deficiency type Chronic Kidney Disease Stage3(CKD3),and it can effectively improve the TCM clinical symptoms as well as the levels of laboratory indicators in the treatment.Furthermore,the effucacy of experimental group is better than control group.2.Correlation analysis showed that serum and urinary Col-Ⅳ were associated with renal function progression and incerased albuminuria,indicating that reducing Col-Ⅳ could effectively reduce the degree of proteinuria leakage,protect the renal function,and delay the progression of CKD.3.After treatment,the urine protein and renal function of the experimental group were improved compared with the control group,and the level of serum and urinary Col-Ⅳ was reduced,suggesting that Yiqiquanzhen Tang may improve the excessive expression of Col-Ⅳ,reduce proteinuria excretion,delay the process of renal fibrosis,thereby improving renal function by slowing down the deposition of extracellular matrix(ECM).4.No apparent side effects were found in the study of Yiqiquanzhen Tang in the treatment of Spleen-Kidney Qi and Yin deficiency type Chronic Kidney Disease stage 3(CKD3),which is safer and more reliable,so it is considered that this formula has certain clinical guiding significance and is confidently suitable for promotion and application.