Study On Clinical Efficacy Of Chaishao Tongbian Granules In Treating Functional Constipation In Children Of Qi Stagnation Type

Objective:To objective evaluation and preliminary evaluation the clinical efficacy of this formula through clinical observation and research of the treatment of Chaish-aotongbian Granules in the treatment of Functional Constipation in Children of Qi Stagnation Type,which lay a solid foundation for in-depth clinical promotion and stu-dy of this formula.Methods:There were seventy-two patients of children with Functional Constipation of Qi Stagnation Type were included.They were arbitrarily divided into 36 patients in the observation group(who were given oral treatment with Chaishaotongbian gra-nules),and 36 patients in the control group(who were given oral treatment with Four grinding soup oral liquid).Both groups were carried out for 2 courses(14 days)of treatment,and followed up for 1 months after the end of treatment.The TCM symptoms of the children pre and post-treatment were recorded and scored,and the efficacy results of each group and between groups were statistically evaluated according to the appropriate statistical methods to objectively assess the clinical efficacy of Chaishao Tongbian Granules in the treatment of Treating Functional Constipation in Children of Qi Stagnation Type.Results:1.The overall efficacy of the observation group and control group is 87.9% and77.4%,which indicated the higher therapeutic effect among observed group than the controlling ones.(P<0.05).2.At the end of the treatment course,the constipation symptoms were improved in both groups(P<0.01).3.The observation group showed a better curative outcome compared with control group,with statistically meaningful variation regarding improved ratings on total,cardinal and minor childhood symptoms(P<0.05).4.The observation group was more effective than the control one in improving the degree of difficult defecation,the stool characteristics and defecation interval of the children(P<0.05).Both groups were improving abdominal distension,belching,the curative effect was equivalent(P>0.05).5.The observation group showed a superior result to the control one that in improving the Poor appetite,chest full,fidgety,depression,P<0.05;the observation group and the control group were dry mouth,bitter mouth,bad breath,the curative effect was equivalent,(P>0.05).6.The observation group showed a superior result to the control one in the onset time of defecation after medicine(P<0.05).7.The recurrence rate of the observation group and control group is 9.1% and19.4%,indicating that The observation group was better than the control group in reduce the recurrence.8.There were no adverse events occurred in both groups of children during the whole clinical study.Conclusion:From observations and clinical studies,Chaishao Tongbian Granules can improve stool characteristics,difficulty in defecation,bloating,belching,fidgety,depres-sion and other symptoms in Functional Constipation in Children of Qi Stagnation Type,shorten the interval between defecation,reduce the frequency of relapses,and no adverse effects were found during the clinical study,it can be further investigated and clinically popularized.