Correlation Between Risk Factors Of Hyperuricemia And Constitution Of Traditional Chinese Medicine And Analysis Of Drug Use Law Of Phlegm Dampness

objective:By analyzing the correlation between the risk factors of hyperuricemia(HUA)and the constitution of traditional Chinese medicine,we can provide guidance for the early prevention and treatment of hyperuricemia and health education.Further,the data mining and analysis results of the typical phlegm dampness constitution were conducted to point out a new direction of medication for the TCM treatment of phlegm dampness constitution hyperuricemia.Methods:The first part of the questionnaire survey,using the case-control study method of questionnaire survey,from november 2021 to november 2022,our hospital nephrology department,rheumatology general internal medicine outpatient clinic,inpatient 406 patients were classified and measured by tcm physique.206 patients with hyperuricemia were included in the observation group and 200 patients with uric acid values were included in the control group for analysis based on inclusion and exclusion criteria.The subjects’ basic information,diet,exercise,life habits,anxiety and depression were collected to determine their TCM physique.Dual logic regression was used to analyze the risk factors of HUA,and it was found that the physique of three types of TCM,namely,wet sputum,damp heat and qi-deficiency,was related to the risk factors of HUA disease.In the second part,the data mining was conducted on the typical body type obtained from the first part of the study that was significantly associated with hyperuricemia-phlegm-dampness,and the literature on Chinese medicine treatment of hyperuricemia in phlegm-damp body type was searched from China Knowledge Network(CNKI),Chinese Science and Technology Journal Full Text Database(VIP),Wanfang and China Biomedical Database(CBM),respectively,and the TCM inheritance was used to We used the TCM heritage platform to analyze the pattern of prescriptions and medications in the treatment of phlegm-damp hyperuricemia in TCM.RESULTS:There was no significant difference in age,sex,smoking,alcohol consumption,exercise,job type,education,hypertension,previous HUA,family history of Fahrenheit/gout,sleep less than 8 hours,diabetes mellitus,anxiety score,depression score between the two groups in the first part of the study,P>0.05.The frequency of BMI and social meals in the observation group was significantly lower than in the control group,P<0.05.There was no significant difference between the two groups,P>0.05.There was no statistically significant difference between the two groups,P>0.05.Potatoes,animal offal,vegetables,mushrooms,lettuce,freshwater fish/shellfish,rice,wheat flour,beans,eggs,beef,lamb,pork,chicken,duck and goose meat,nuts,dairy,fruit and confectionery/snacks did not differ significantly in frequency between the two groups.The univariate analysis of these difference indicators was included in the factor analysis using hyperuricemia = 1 and non-hyperuricemia = 0,and the risk factors for hyperuricemia were analyzed using logistic regression.Social gathering frequency and gender did not significantly affect hyperuricemia,with BMI and frequency of alcohol consumption being risk factors for hyperuricemia.Among the risk factors for hyperuricemia hyperuricemia phlegm wet predictive model Log(P)= 0.288× BMI-3.693 × coarse meat/ fondue broth score 1535 × seafood consumption score + 2.414 × alcohol score + 5.645.Among the risk factors for hyperuricemia,there was a positive correlation between wet and hot body mass index and no significant association with other risk factors.The correlation between Qi and hyperuricemia risk factors was not significant.The second part of literature and platform analysis revealed that 60 prescriptions,122 herbs,≥ 5 times 19 times and ≥ 20 times 6 times were used to treat the phlegm and wet quality of hyperuricemia,including Tuling,Tuling,Coix Seed,Albino,Chen Pi,Ze Xie,nature and smell of Guiping,Wen,Cold,Gan,Bittersweet,3 meridians,Spleen and stomach.Drug correlation analysis yielded 9 core drug combinations.Seven new drugs were identified by Cluster analysis using 19 high frequency herbs ≥ 5 times.Conclusion:Part I,BMI,thick meat/ fondue soup,seafood and alcohol consumption are all risk factors for hyperuricemia.The proportion of hyperuricemia was higher in phlegm wet constitution,hot and humid constitution and qi deficiency constitution.phlegm-dampness constitution was positively correlated with the frequency of eating thick meat/hot pot soup and seafood.Among the risk factors for hyperuricemia,there was a positive correlation between Damp-heat constitution and body mass index.The second part,in the traditional Chinese medicine prescription law of phlegm dampness constitution of hyperuricemia,it is found that Poria cocos and Smilax glabra are high-frequency drugs,and seven new drug combinations are obtained,which are mainly based on the principles of resolving phlegm and removing blood stasis,promoting arthralgia and unblocking collaterals,clearing heat and removing dampness,pointing out new drug directions for the traditional Chinese medicine treatment of phlegm dampness constitution hyperuricemia.