| Objective: To explore the distribution characteristics of TCM syndromes and drug use in patients with recurrent angina pectoris after PCI by analyzing relevant literature.To provide useful reference for clinical doctors in syndrome differentiation and treatment.Methods: This study used the method of literature analysis,according to the search strategy,the literature in the target database was searched,the retrieved literature was recorded into the Endnote software for management,and was screened according to the established inclusion and exclusion criteria,the syndrome,syndrome element and medication in the literature meeting the inclusion criteria were extracted,the database was established,and the statistical analysis was carried out.Results: 1.48 literatures with definite syndrome differentiation types were included,including11 journals and 37 master’s degree papers.A total of 14 TCM syndromes were extracted,and the total frequency was 48 times.The most common TCM syndromes were qi deficiency and blood stasis,phlegm-stasis interjunction and qi stagnation and blood stasis.The results of syndrome differentiation of deficiency and blood stasis showed that there were 29 mixed syndrome of deficiency and blood stasis,accounting for 60.42%,mainly syndrome of Qi deficiency and blood stasis(22 times),followed by 17 positive syndrome,accounting for35.41%,mainly syndrome of phlegm-stasis and blood stasis(7 times)and syndrome of Qi stagnation and blood stasis(6 times).The proportion of deficiency syndrome was the least,which was 2 times in total,accounting for 4.17%,including the deficiency of Qi and Yin and the deficiency of spleen and kidney.There were 12 syndromic elements,including 9 pathologic syndrome elements and 3 pathologic syndrome elements.The pathogenic syndrome elements were blood stasis,qi deficiency,phlegm,qi stagnation,Yin deficiency,blood deficiency,qi depression,poison and heat(ranked by frequency from high to low).Among them,blood stasis accounted for 44.45%.The three syndromes were heart,kidney and spleen(ranked from high frequency to low frequency).Among them,the heart of reached 57.14% occupied the main position.To justify syndrome elements for clustering analysis,the result get three categories:blood stasis for category,qi deficiency as category,phlegm,qi and to: heart,Yin deficiency,kidney,blood deficiency,air pocket,heat,spleen,poison.Association rule analysis of syndrome elements showed that blood stasis → Qi deficiency had the highest rule support degree(55.102),confidence degree(96.296)and gain(1.049).2.69 literatures related to oral TCM treatment,41 journals and 28 master degree theses were finally included.A total of 69 TCM prescriptions were extracted,and 114 TCM flavors were used for 713 times.The average frequency of use of each flavor was 6.25 times.33 highfrequency drugs were used 546 times,accounting for 76.58% of the total number of drugs.Among high frequency medicines,salvia miltiorrhiza was the most frequently used drug,46 times in total,accounting for 8.42%.Top five drugs were salvia miltiorrhiza,Ligusticum Chuanxiong,licorice,Radix astragalus and angelica sinensis,which were used 46,42,40,34 and 30 times respectively,accounting for a total proportion 35.17%.The results of clustering analysis of high-frequency drugs were grouped into 5 categories,the first category was salvia miltiorrhiza,Ligusticum Chuanxiong and licorice.The second class were astragalus membranaceus and Angelica sinensis.The third class were peach kernel,panax notoginseng,trichosanthes,ginseng and poria cocos;The fourth class were safflower,red peony and Fructus aurantii;The fifth class included Rhizoma corydalis,Rhizome macrostemon,bupleurum,Ground dragon,codonopsis codonopsis,osmanthus twig,Radix achyranthes,Radix anthematoides,Radix ophiopogonis,Radix atractylodes,Pueraria,Leech,Rehmannia,Paeony,Tangerine peel,platycodon,Schisandra,sand kernel.33 association rules were obtained from the analysis of high frequency Chinese herbs,and the highest support was obtained from Ligusticum Chuanxiong → Angelica sinensis.Conclusions :1.The common symptoms of recurrent angina pectoris after PCI are Qi deficiency and blood stasis syndrome,phlegm-stasis interjunction syndrome,Qi stagnation and blood stasis syndrome.The main syndromic elements were blood stasis,qi deficiency,spittoon coagulation and qi stagnation.2.The commonly used drugs for angina pectoris after PCI of coronary heart disease are salvia miltiorrhiza,Ligusticum Chuanxiong,licorice,Radix astragalus,angelica,safflower,Fructus aurantii,Red Peony root,peach kernel,Trichosanthes,Trichosanthes notoginseng,Poria,ginseng,pinellia pinellia,bupleurum,codonopsis codontiorum,Rhizome,Rhizoma macrostemon,Yu gold,cassia twig,Radix ophiopogonis,Radix puerariae,Radix rehmanniae,leechi,Radix orange peel,Radix platycodon grandiflorum,Radix ambrosiae,and five Weizi;The commonly used pair is Chuanxiong-Angelica: the commonly used prescription is Xuefu Zhuyu decoction. |
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