Study On Effect Of Ciprofol On Perioperative Stress Response In Patients Undergoing Ankle Osteotomy Surgery

OBJECTIVE:To observe the effect of intravenous sedation with ciprofol and dexmedetomidine on perioperative stress response in patients undergoing ankle osteotomy surgery.METHODS:A prospective study method was used to include 40 patients（21 males and 19females）who underwent ankle osteotomy surgery under combined spinal-epidural anesthesia in the afternoon of July to September 2022 in our hospital.They were randomly divided into ciprofol group（group C）and dexmedetomidine group（group D）with 20 cases in each group.Group C was given 0.25 mg/kg of ciprofol（injection time 30 s）,and then continuously pumped at 0.6 mg·kg^-1·h^-1.Group D was given a loading dose of dexmedetomidine 0.8μg/kg（micropump infusion for 10 min）,and then continuously pumped at 0.2μg·kg^-1·h^-1.The Narcotrend index（NI）,mean arterial pressure（MAP）and heart rate（HR）of the two groups were recorded before treatment（T₀）,10 min after treatment（T₁）,20 min after treatment（T₂）,30 min after treatment（T₃）and at the end of operation（T₄）.Venous blood was taken at T₀,T₄and the day after operation to determine plasma noradrenaline（NE）and serum cortisol（Cor）levels,and the degree of forgetting and the incidence of adverse reactions were recorded.RESULTS:The MAP of the ciprofol group was significantly lower than that of the dexmedetomidine group（P<0.05）;NI in the ciprofol group was significantly higher than that in the dexmedetomidine group（P<0.05）;At T₄,the contents of NE and Cor in the ciprofol group were significantly lower than those in the dexmedetomidine group（P<0.05）;The incidence of bradycardia in the ciprofol group was significantly lower than that in the dexmedetomidine group（P<0.05）;The incidence of respiratory depression in the ciprofol group was significantly higher than that in the dexmedetomidine group（P<0.05）.CONCLUSION:As an auxiliary sedative for combined spinal-epidural anesthesia,ciprofol has an effective and safe sedative effect in clinical application,which can effectively reduce the perioperative stress response of patients undergoing ankle osteotomy surgery.Compared with dexmedetomidine,ciprofol has a more outstanding effect in reducing stress response,providing new ideas and methods for the comfort of clinical anesthesia and rapid postoperative rehabilitation of patients.