| Objective: To observe the clinical efficacy and drug safety of Cerebral Richong-9 Flavor Pill in the treatment of migraine(blood-heat headache).Methods: Ninety three patients with migraine(blood-heat headache)who met the criteria were randomly divided into 3 groups,each group with 30 cases,respectively,observation group,control group 1 and control group 2.The treatment group was given Cerebral Rin-9Flavor Pills,15 capsules every night before bedtime.Control group 1 was given Hu Richa-6flavor pills,15 capsules every night before bedtime.Control group 2 was given flunarizine hydrochloride capsules at 5 mg every night before bedtime,and all three groups were treated for 21 days.The changes of efficacy indexes such as VAS score,headache score and Mongolian medical syndrome evaluation scale were observed before treatment,7 days after treatment,14 days after treatment,and 21 days after treatment,and blood routine,urine routine,stool routine,liver and kidney function,blood glucose,blood lipid,electrocardiogram and other examinations were performed before and after treatment to evaluate the effectiveness and safety Naorichong-9 pill.Result:1.In terms of VAS score,intra-group comparison: after 7 days,14 days and 21 days of treatment,the VAS score of the three groups was lower than that before treatment(p<0.05),indicating that the headache degree of the three groups was relieved after treatment.Comparison between groups: Compared with control group 1,the observation group had significantly better headache relief than control group 1(p<0.05)after 14 days of treatment,and there was no significant difference with control group 1 after 7 days and 21 days of treatment(p>0.05).Compared with the control group 2,the headache relief of the observation group after 7 days,14 days and 21 days of treatment was significantly better than that of the control group 2(p<0.05).2.In terms of headache score,intra-group comparison: the headache scores of the three groups of patients after 7 days,14 days and 21 days of treatment were all lower than those before treatment(p<0.05),indicating that the headache degree,attack frequency,duration and accompanying symptoms(nausea,vomiting,photophobia and phonophobia)of the three groups of patients have been alleviated after treatment.Comparison between groups: After 14 days of treatment,the remission degree of the observation group was obviously better than that of control group 1 and control group 2(p<0.05),but there was no significant difference between the observation group and control group 1 and control group2 after 7 days and 21 days of treatment(P > 0.05).3.In the aspect of Mongolian medicine syndrome score,intra-group comparison: After 7 days,14 days and 21 days of treatment,the scores of Mongolian medicine syndrome in the three groups were lower than those before treatment(p<0.05),indicating that the primary and secondary symptoms of Mongolian medicine in the three groups were relieved after treatment.Comparison between groups: The remission degree of primary and secondary symptoms of Mongolian medicine in the observation group was significantly better than that in the control group 1 and 2 after 14 days of treatment(P < 0.05),but there was no significant difference between the observation group and the control group 1 and 2 after 7 days and 21 days of treatment(P > 0.05).4.In terms of clinical efficacy,after 21 days of treatment,the total effective rate was 93.10% in the observation group,82.14% in the control group and 81.48% in the control group,with no statistical significance(P > 0.05).5.As for the curative effect of Mongolian medicine syndrome,after 21 days of treatment,the total effective rate of the observation group was100.00%,that of the control group 1 was 96.43%,and that of the control group 2 was 96.30%,with no statistical significance(P > 0.05).6.In terms of safety,there were no adverse reactions in the observation group and the control group 1 during the study.In the control group 2,three patients were sleepy,and two of them were accompanied by slight fatigue(the patients did not complain of other discomfort,and the adverse reactions were tolerable,so they did not stop taking the drug): there were no obvious abnormalities in the general vital signs and laboratory tests of the three groups before and after treatment,and the laboratory tests before and after treatment showed that P>0.05 by paired sample T-test,and the difference was not statistically significant.Conclusion: 1.Naorichong-9 pill can reduce the degree of headache,the number of attacks,the duration,the accompanying symptoms(nausea,vomiting,photophobia,phobia)and the main and secondary symptoms of Mongolian doctors,and its onset speed is fast,and the short-term efficacy is more significant;2.There were no adverse reactions during the treatment of Naorichong-9 pill,no liver and kidney function damage,and good safety. |
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