Study On Application Of Powder Formulation In "Synopsis Of The The Golden Chamber"

Research objective:Through the method of literature research,this paper aims to restore the details of the application of powder in "Synopsis of the Golden Chamber",and to explore the characteristic advantages and application rules of powder formulations in "Synopsis of the Golden Chamber",to analyzes Zhang Zhongjing’s thinking of using powder formulations and to provide theoretical basis for modern clinical application of powder formulation.Research method:This paper mainly adopts the method of literature research: 1.Through searching the "Chinese Medical Dictionary " comb the ancient doctors of the use of powder formulation theory.2.By comparing the formulations in "Synopsis of the Golden Chamber" in the two editions by Wu Qian and Deng Zhen,the controversial formulations in the two editions are discussed.The final formulations were summarized by preparation method,dosage,delivery method and solvent and excipients.3.The theory,experience and medical records of the application of the powder formulation of the "Synopsis of the Golden Chamber" were collected by searching the databases of the Chinese Medical Dictionary",CNKI,etc.,and the characteristics and rules of the application of the powder formulation of the "Synopsis of the Golden Chamber" were summarized and analyzed according to the literature.4.The development and application of powder were discussed in combination with modern pharmaceutical technologyResearch Results:1.After combing and finding that the ancient doctor application of powder theory mainly has the following six points: first,according to the use of drug properties,such as small poison should be powder;Two,according to the treatment method,such as dispelling dampness and wind need to use powder;Three,according to the location of the disease,such as disease in meridians,limbs,stomach and intestines;Four,according to the course of disease,such as long illness need to use powder;Five,according to disease condition,such as emergency illness need to use powder;Six,according to the season,such as spring and autumn are better time to use powder.2.After discussion and screening,a total of 34 formulations were included in "Chinese Medical Dictionary ",of which 29 were powder that taken directly,3were powder that need to be boiled,and 3 were used for external use.Bu Liu Xing San was both taken as powder and used as powder for external use.The rest of the controversial decoction formulas named after soups are not included in this study.3.The preparation methods of powder in "Synopsis of the Golden Chamber" mainly include "pestling into powder","triturating and sifting ",and " triturating and sifting separately,then mixing and grinding ".The powder formulation prepared by different methods in "Synopsis of the Golden Chamber" have different powder sizes.In the preparation of powder,there are different kinds of mashing separately and mixed mashing according to drug characteristics.The dosage of the powder used in "Synopsis of the Golden Chamber" is generally low compared with the dosage of modern clinical drugs.Various solvents are used to deliver dosing powder,which can be selected according to specific conditions: generally,rice soup is used to deliver dosing powder,which can introduce medicine into the stomach to strengthen and protect stomach qi;Rice congee can specially tonify the spleen and stomach,invigorate qi and producing fluid;Barley porridge can regulates the liver and nourishes the spleen,promotes the movement of qi in the human medium jiao,and promotes the downward movement of qi;Cold fermented water of rice soup can clear away heat and toxin;Warm fermented water of rice soup can enhance the antiemetic effect of drugs;Wine can cheer up the spirit,tonify Yang qi and promote blood circulation;Boiling water can help the body warm and dispel cold,sweat and dispel evil;The first pail of well water at dawn can reinforce yin and clear away heat;Black bean sauce can promote the stagnation of the qi in the middle jiao;Jujube cooking juice can soften the effects of severe drugs;The lead powder helps the powder maintain its shape.4.The application characteristics and rules of the powder formulation in "Synopsis of the Golden Chamber" are mainly divided into the following ten points:First,relieve bladder moisture need to use powder;Two,to acts on the stomach and intestines need to use powder;Three,to remove pathological product of zangfu-organs need to use powder;Four,localized lesion need to use powder;Five,strong drugs need to use powder;Six,emetic need to use powder;Seven,use powder for emergency treatment;Eight,to control the dosage of medicine and slow release of medicine need to use powder;Nine,to save medicinal materials and be easy for long-term use;Ten: according to the doctor’s habit of using powder.5.Modern clinical TCM granules are formulated on the basis of decoction,and can not be directly equated with powder formulations.But suspension type granules can combine the advantages of granule and powder formulations.Ultrafine grinding technology can not completely replace the general grinding technology,the particle size of powder grinding should be analyzed according to the specific drug and prescription.Conclusion:In "Synopsis of the Golden Chamber",there are various forms of powder application,and there are many noteworthy details in the preparation process and delivery method,which provide abundant data for the study of the theory of powder formulation.Powder formulation has its dosage form advantage for specific etiology,disease location,disease syndrome and treatment.There are corresponding conditions for clinical conversion of prescription form,which has certain guiding significance for clinical application and development of modern dosage form.