| Objective: This article aims to study the application of Professor Zhang Xiaoping’s Choleretic Anti-swelling Formula for the treatment of chronic calculous cholecystitis with humid heat stasis,and explore the clinical efficacy and safety of TCM symptoms,gallbladder ultrasound,stone size and safety indicators of the enrolled patients before and after treatment,so as to provide new ideas for the clinical treatment of chronic calculous cholecystitis with humid heat stasis,and provide clinical evidence-based basis for the promotion of famous and old Chinese medicine experience.Methods: From June 2021 to November 2022,70 patients with chronic calculous cholecystitis who attended the Second Department of Gastroenterology Clinic of the Affiliated Hospital of Jiangxi University of Chinese Medicine and the outpatient clinic of Zhang Xiaoping’s studio of the Chinese Medical Hall were collected,and70 patients were divided into treatment and control groups according to the random number table method,with 35 cases in each group.35 patients in the treatment group took Zhang’s choleretic anti-swelling formula,the prescription was a no-frying granule uniformly prepared by the granule pharmacy of the Affiliated Hospital of Jiangxi University of Chinese Medicine,usage and dosage: one compartment/bag at a time,150 ml of warm boiled water;Take it half an hour to one hour after lunch and dinner,4 weeks is 1 course of treatment,and 8 weeks are continuous.Control group oral choleshu capsules,specifications: 0.45 g per capsule,30 capsules/box;Dosage:Oral,2 capsules at a time,3 times a day,4 weeks for 1 course of treatment,continuous use for 8 weeks.After the end of the treatment cycle,the statistical software SPSS26.0 was used to analyze the changes of TCM syndrome quantification score table,gallbladder color ultrasound score table and stone size score table before and after treatment in the two groups,and evaluated their efficacy and safety through relevant indicators.Result:(1)By counting the age,sex and course of the two groups,it was found that there was no significant difference(P >0.05)between the two groups,indicating that there was no difference in the baseline situation between the two groups and there was a contrast.(2)Analysis of the degree of disease before treatment between the two groups:There was no significant difference in the TCM syndrome score(main disease,secondary disease,total score),gallbladder color Doppler ultrasound score,and stone size score before treatment between the treatment group and the control group,P >0.05.(3)TCM syndrome: the total points of TCM symptoms before treatment were 23.50(18.75,27.00)and 6.00(3.00,8.00),P <0.01 in the treatment group,and the total points of TCM symptoms before treatment in the control group were 23.50(18.00,26.00),and the total points after treatment were 10.00(6.75,16.00)and P <0.01.(4)Gallbladder ultrasound: the pre-treatment gallbladder ultrasound score was4.00(4.00,6.00),the post-treatment score was 2.00(0.00,4.00),P <0.01;the control group had a pre-treatment gallbladder ultrasound score of 4.00(4.00,6.00),and a post-treatment score of 2.00(2.00,4.00)and a P <0.01,and the degree of decline in the treatment group was higher than that of the control group.(5)Stone size: pre-treatment stone size integration 4.00(4.00,6.00),post-treatment score 2.00(0.00,2.00),P <0.01;control group pre-treatment stone size integration 4.00(4.00,4.50),post-treatment score 2.00(2.00,2.00),P <0.01,both groups had significant treatment effects,but the improvement effect of the treatment group was greater than that of the control group.(6)Total efficacy: After completing the trial cycle in both groups,the data were summatively analyzed and concluded that 6 cases(4 cases of sedimentous gallstones)were cured among the 34 cases in the treatment group,12 cases were effective,11 cases were effective,5 cases were ineffective,and the total effective rate was 85.29%;Among the 34 cases in the control group,1 case(sedimentous gallstones)was cured,13 cases were effective,12 cases were effective,8 cases were ineffective,and the total effective rate was 76.47%,and the total effective rate of the treatment group was significantly higher than that of the control group,so the treatment effect of Zhang’s choleretic antiswelling formula for chronic calculous cholecystitis was higher than that of cholestatic capsule.There were a total of 5 patients with sedimentous stones in the treatment group,of which 4 cases were cured,and 4 patients with sedimentous stones in the control group,of which 1 case was cured,it can be seen that the drugs used in both groups have a better effect on sediment-like stones,and the efficacy of the treatment group in the two groups is significantly better than that in the control group,so it is known that Zhang’s choleretic anti-swelling formula may have more advantages than other stones in the treatment of sedimentous gallstones.(7)Safety analysis: Through the observation of safety index,it was found that there were no clinically significant adverse reactions and toxic and side effects in the whole process of this study,which showed that Zhang’s Lidan Xiaozhang recipe and Danshu capsule had high safety in the treatment of chronic calculous cholecystitis with damp-heat and blood stasis.Conclusion: Zhang’s Choleretic Anti-swelling Formula and Chole Shu Capsule have certain curative effects in the treatment of chronic calculous cholecystitis with humid heat stasis,but Zhang’s Choleretic Anti-swelling Formula has a more significant efficacy and can be promoted and used clinically. |
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