Discussion On The Treatment Of Acne Of Damp-Heat Type Of Spleen And Stomach With Qingwei Powder And Fire Acupuncture Based On The Theory Of "Fire Stagnaion"

Purpose:To observe the clinical efficacy and mechanism of the treatment of acne of the damp heat type of spleen and stomach with the combination of fire needle and the Qingwei powder plus or minus oral administration based on the theory of“ release of fire stagnation”,and to explore whether the combination of the Qingwei powder plus or minus oral administration and fire needle has a significant effect on the scores of the traditional Chinese medicine syndromes,the skin lesions,the quality of life,the safety and sex hormones of acne and so on,so as to provide a better treatment plan.Methods:80 patients of acne with the damp heat type of spleen and stomach were randomly divided into two groups according to the principle of parallel control: the treatment group(the Qingwei power plus or minus oral administration combined with fire acupuncture treatment)and the control group(giving the Qingwei power plus or minus oral administration combined with fusidic acid cream for external use).The treatment time was 4 weeks.Form the treatment of the beginning and the ending,needing to observe and record the traditional Chinese medicine syndrome score of the patients,at the same time,also need to keep a record of acne comprehensive grading system score,skin disease quality of life index score and sex hormone level(testosterone,estradiol,luteinizing hormone)and so on,so as to comprehensively evaluate the treatment effect.Result:1.General situation comparison: 80 patients with acne were included.After analyzing the collected data,the general situation comparison of the two groups of patients(age,sex,course of disease)was consistent with the square variance and normal distribution of data,and P>0.05,it indicates that there was no obviously statistical difference,and the two groups were balanced and comparable.2.The Traditional Chinese Medicine symptom score: The score of traditional Chinese medicine symptoms in the two groups obviously decreased at the end of treatment compared with that before treatment,and after the horizontal comparison,there was statistically significant difference between the same group from start to finish the treatment(P<0.05).However,after the longitudinal comparison,there was no obviously significant difference in the traditional Chinese medicine symptom score between the two groups(P>0.05).The two kinds of results showed that both groups could improve acne patients the symptoms of the skin pain,the bitter mouth and greasy face.3.Skin disease quality of life index scale score of acne patients: After the end of treatment,the dermatology quality of life index scale score of the treatment group and the control group both decreased,and before and after treatment with the horizontal comparison,the difference between the same group was statistically significant(P<0.05).However,after longitudinal comparison,the score of the dermatology quality of life index scale score between the two groups was P>0.05,indicating that there was no statistically significant difference between the two groups.It shows that both groups can improve the quality of life of patients and both groups have the same effect.4.Acne comprehensive grading system score: For improving the skin lesions of patients,there was no statistically significant difference between the comparison of the two groups before treatment(P>0.05);at the end of the treatment,the difference between the two groups was statistically significant(P<0.05).The same group after the horizontal comparison,the result is P<0.05,indicating that the acne comprehensive grading system score of the two groups both decreased after treatment,and the skin lesions could be improved,but the improvement effect of the treatment group was better than that of the control group.5.Clinical efficacy: the total effective rate of 94.80% in the treatment group is much higher than that of 87.50% in the control group.The clinical efficacy of the two groups was compared by rank sum test,the result is Z=-2.407,P<0.05(P=0.016).It shows that the difference between the two groups was statistically significant,indicating that the clinical efficacy of the control group was significantly lower than that of the treatment group.6.Sex hormone level: To evaluate the effect of Qingwei powder plus or minus oral administration combined with fire acupuncture on sex hormone level,comparing the content of LH,E2 and T in serum before and after treatment,and find that there is no statistically significant difference between the two groups before and after treatment because the result is P>0.05.The difference between the same group before and after treatment was statistically significant(P<0.05).7.Safety evaluation: during the treatment,there was one patient who was treated with fire needle due to unbearable pain and suspended for a few minutes,then got better and did not fall off;and no other adverse conditions such as facial redness and infection;at the same time,and two patients had mild gastrointestinal discomfort when they were taking Chinese medicine,but the symptoms were relieved after adjusting the dosage.The patients were instructed to avoid taking Chinese medicine on an empty stomach and to take warm medicine half an hour after have a eating,which did not affect the treatment.Conclusion:1.Compared with Qingwei powder plus or minus oral administration combined with fusidic acid cream for external use,the combination of fire needle therapy has better curative effect,no obviously adverse reactions,higher safety,lower cost,and is worth promoting.2.The mechanism of Qingwei powder plus or minus oral administration Combined with fire acupuncture treatment is related to the levels of sex hormones(T,E2,LH)。...