| Objectives: In this study,we used the combination of kidney tonifying and phlegm-transforming formula and metformin to treat PCOS-IR patients,and analyzed the clinical comprehensive efficacy of kidney tonifying and phlegm-transforming formula combined with metformin in treating PCOS-IR patients by observing the changes of their TCM symptom scores,BMI levels and glucose metabolism indexes before and after treatment,in order to provide new methods for the clinical treatment of this disease.Research methods: The subjects in this study were all from the gynecological clinic of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,and the treatment period was from December 2020 to December 2022.64 cases that met the diagnosis of polycystic ovary syndrome with insulin resistance in Western medicine and were identified as kidney deficiency,phlegm and dampness in Chinese medicine were selected as samples.According to random number table method,these 64 cases were separated into 32 cases each in the treatment group and control group.The control group received metformin and traditional Chinese medicine placebo,and the treatment group received kidney tonifying and phlegm-transforming formula combined with metformin.The changes in the TCM symptom scores,BMI level and glucose metabolism indexes of the two groups were observed before and after treatment,and the comprehensive curative effect was analyzed,and the menstrual cycle of the past two months were follow-up recorded after the end of treatment.Statistical analysis was performed using Excel table organization and SPSS26.0 to finally compare where the differences in efficacy between the two treatment groups were.The result of the study:(1)The age,disease duration,BMI,FPG,1h glucose,2h glucose,FINS,1h insulin,2h insulin,HOMA-IR,total TCM symptom score,and individual TCM symptom scores of the two groups were statistically analyzed before treatment,and there were no significant differences(P>0.05),and they were all comparable.(2)Comparative analysis of the total TCM symptom score: The results of intra-group and inter-group comparison the total score of TCM symptom between the two groups after treatment,indicated that there were significant differences(P<0.05),suggesting that the clinical symptoms of TCM could be improved to different degrees under the treatment methods of the two groups,and the curative effect of the treatment group was obviously superior.(3)Comparative analysis of individual TCM symptoms scores: The two groups were compared within the group founded that there were significant differences(P<0.05).The two groups were compared with each other after treatment showed that there were significant differences in the seven aspects of menstrual cycle,menstrual flow,lumbar and knee tenderness,dizziness and tinnitus,obesity,chest and abdomen fullness,and head and body heaviness(P<0.05),indicating that the treatment group had better effects in the above seven aspects.(4)Comparative analysis of BMI levels: A significant difference was founded in BMI levels between the two groups after treatment,both within and between groups(P<0.05),implying that both groups had certain effects on reducing the weight of patients,and the treatment group had more advantages in decreasing BMI level.(5)Comparative analysis of blood glucose levels: The two groups were compared within the group,they had significant differences(P<0.05),revealing that the treatment of both groups could be able to reduce blood glucose levels.The comparison between the two groups after treatment had no significant differences(P>0.05),indicated that they were equally effective.(6)Comparative analysis of insulin levels between: The comparison between the two groups before and after treatment showed significant differences(P<0.05),indicating that both groups were able to reduce insulin levels in three time phases.The comparison between the two groups after treatment,it was founded that there were significant differences in reducing FINS and 1h insulin levels(P<0.05),explaining that the treatment group had better efficacy in reducing FINS and 1h insulin levels.(7)Comparative analysis of insulin resistance index(HOMA-IR):Both groups were compared within and between groups,and the results founded significant differences(P<0.05),indicating that both groups were able to improve insulin resistance,and the treatment group was more effective in improving insulin resistance.(8)Comprehensive efficacy comparative analysis: Comprehensive analysis of the two groups of the observed targets,the total effective rates were respectively 82.76% and 93.33% for the control and treatment groups.The comparison results of the comprehensive curation effect between the two groups revealed a significant difference(Z=-3.033,P=0.002<0.05),implying that the treatment group had superior effect and more accurate efficacy.(9)Analysis of the follow-up results: In the third month after the end of the treatment of this study,the two groups of patients were followed up with the menstrual cycle of the past two months,and after analyzing the follow-up data,it was founded that there were significant differences between the two groups(Z=-2.326,P=0.020<0.05),and the effective efficiency were respectively 90.00% and 72.41% for the treatment group and the control group.Thus,it is speculated that the combined treatment of Chinese and Western medicine treatment on PCOS-IR patients also played a role in the long-term efficacy.Conclusion:In this study,we used the combination of kidney tonifying and phlegm-transforming formula and metformin to treat PCOS-IR patients,can effectively improve the clinical symptoms of TCM,reduce BMI level,improve glucose metabolism and insulin resistance,and the efficacy of combining traditional Chinese medicine and Western medicine is more accurate,which is worthy of further clinical promotion. |
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