Short-term Macular Vascular Density And Electrophysiological Changes After PRP In Patients With Diabetic Retinopathy

Objective:The purpose of this study was to compare the electrophysiology,macular vascular density,and best corrected visual acuity of patients with diabetic retinopathy before and after PRP.Methods:20 individuals(38 eyes)with type 2 diabetes who were diagnosed with diabetes retinopathy at Shanxi Medical University’s First Hospital served as the study’s subjects,including 13 men(25 eyes)and 7 women(13 eyes),with the age of 59.4 ±7.51 years.The oldest patient was 73 years old,while the youngest was 45.Perform detailed ophthalmic examinations on the patient,including visual acuity,optical coherence tomography(OCT),optical coherence tomography angiography(OCTA),intraocular pressure,optometry,slit lamp examination,mydriatic fundus examination,fundus photography,fundus fluorescein angiography,and multifocal ERG examination.Record the patient’s best corrected visual acuity(BCVA),vascular density in the macular region,and changes in multifocal electrophysiological amplitude density and latency time.After an experienced doctor diagnosed diabetes retinopathy,he performed panretinal laser photocoagulation,recorded the examination data before,one week after and one month after surgery,and analyzed the data using statistical methods Results:After PRP,visual acuity reduced in diabetic retinopathy patients one week after surgery with a statistically significant difference of P 0.05,but not significantly different at one month after surgery(P > 0.05).One month after surgery,there was a substantial difference in the macula’s vascular density with a significant change of P 0.05.The multifocal ERG’s P1 wave amplitude densities for rings 3,4,and 5 at one week after surgery.One week postoperatively,the P1,3 and 5 ring amplitude densities of the multifocal ERG were statistically significant at P 0.05,and one month postoperatively,the 1,3 and 5 ring amplitude densities were statistically significant at P 0.05.At one week and one month postoperatively,rings 1,2,3,4 and 5’s P1 wave latency periods in the multifocal ERG showed a significant difference with P values less than 0.05.Preoperative BCVA,macular vascular density,P1 wave amplitude density of multifocal ERG,and latency time were not correlated with one another in this investigation.Following surgery,BCVA was found to correlate with 1 ring latency time at P 0.05 one week later and with 1 ring amplitude density and latency time at P 0.05 one month later,all of which had statistically significant differences.However,according to OCTA,none of the macular vascular density parameters were associated with the mf-ERG parameters.Conclusion:After PRP,patients with diabetic retinopathy showed marginal or even decreased visual acuity,increased macular vessel density compared to before,increased multifocal ERG P1 wave amplitude density and shortened latency,indicating improved macular function,but there was no correlation between macular vessel density and mf-ERG electrophysiological parameters observed by OCTA.