| ObjectiveBy observing the recurrence and metastasis of the two groups of patients with triple-negative breast cancer after choosing different treatment regimens during the tr eatment window,the change of T immune lymphocyte population,the value of vasc ular endothelial growth factor(VEGF),the change of TCM syndrome score and the change of Karl Karl Fischer Quality of Life Scale,the clinical efficacy of Yiai Shu gan prescription in the prevention and treatment of recurrence and metastasis of post operative triple-negative breast cancer was comprehensively evaluated.It provides the oretical support for its further clinical promotion.MethodsA total of 62 patients with triple-negative breast cancer who had completed sta ndardized chemoradiotherapy and chemotherapy were admitted to the Department of Breast and Oncology of Shanxi Provincial Hospital of Traditional Chinese Medicine from January 2021 to May 2021,and the TCM identified as hepatic depressed sput um coagulation.The random number control method was used.According to the ran dom number table and combined with whether the patient can adhere to the long-ter m oral Chinese medicine wishes,it was divided into two groups,31 cases in the t reatment group and 31 cases in the control group.The control group was given dail y reexamination and treatment(Kushen Injection,Thymosin Injection,hospitalization for 15 days every three months).The treatment group was given oral Yiai Shugan prescription on the basis of the control group(composition:Radix Bupleuri,Radix Curcumae,Fructus Trichosanthis,Shancigu,Solanum lyratum,Astragalus membranace us,etc.).Oral method:one dose per day,200ml,morning and evening,21 doses per month,oral administration for 3 months,stop for 1 month,and so on).After 18 months of treatment,the relevant efficacy indicators and changes in the clinical symptoms of patients were observed,and the clinical efficacy of Yiai Shugan prescri ptionwas comprehensively evaluated.ResultsThe pre-enrollment age,surgical method,disease stage,whether there was axilla ry lymph node metastasis on the affected side,TCM symptom scores,and immune cell correlation indexes were compared between the two groups,and there was no s ignificant difference(P>0.05)after statistical analysis,indicating that the data of the two groups were comparable.Through two different ways of treatment,the results showed that:1.T immune lymphocyte population:the two groups of patients were compared with before treatment after treatment,and the average value of relevant indicators w as increased.It has been shown that both treatment modalities have the effect of im proving the body’s immune function.Compared with the data of the two groups aft er treatment,it was concluded that the effect of the treatment group on improving i mmunity was more obvious(P<0.05).2.vascular endothelial growth factor(VEGF):After treatment between the two groups,the VEGF values of the treatment group were significantly lower than those in the control group(p<0.05),indicating that the treatment group was better than th e control group in inhibiting the growth of tumor vascular endothelium.3.TCM clinical symptome scores:The mean total points of symptom points of the two groups before and after treatment were compared,and the values decreased(P<0.05),and the effect of the treatment group was more obvious(P<0.05),and it was concluded that the treatment group had a better effect on clinical sympto ms.4.Recurrence and metastasis:After treatment,there was no significant differenc e in relapsed metastasis between the two groups(P>0.05).It is concluded that long-t erm oral treatment of Yiai Shugan prescription can significantly reduce the recurrenc e and metastasis rate of postoperative TNBC patients.5.There was a significant difference in recurrent metastasis between the two gro ups after treatment(P<0.05).According to the comparison of the number of relapse d metastases and the metastasis sites in the two groups,it was found that the distan t metastasis rate of TNBC was higher than the local recurrence rate,and the probab ility of bone metastasis and lung metastasis was the largest.It has some clinical sign ificance.6.Liver and kidney function before and after treatment:There was no significan t difference between ALT,AST and Cr before and after treatment group of long-ter m oral traditional Chinese medicine(P>0.05),After treatment,BUN was significantly lower than before treatment(P<0.05).It shows that long-term oral anticancer and liv er thinning prescription will not cause malignant effects on liver and kidney functio n,and has a certain degree of safety.7.Analysis of related factors in this study:the more lymph node metastases,the later the TNM stage,the extreme anxiety and depression of patients after surgery ar e independent risk factors for recurrence and metastasis of triple-negative breast can cer,and long-term oral treatment of suppressive carcinoma Shugan prescription after surgery is a protective factor to prevent cancer recurrence and metastasis.ConclusionOral administration of Yiai Shugan prescription after operation in patients with TNBC of liver depression and phlegm coagulation type can effectively improve the immune function of the body,Inhibit VEGF,reduce the risk of recurrence and meta stasis of this type of breast cancer.It can also improve the clinical symptoms of pa tients,improve their quality of life after operation,and produce good clinical efficac y,and show it is safe and feasible. |
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